Proof of Concept Study of Cognitive Improvement in Patients With Schizophrenia



Status:Completed
Conditions:Schizophrenia
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 55
Updated:10/14/2017
Start Date:August 2007
End Date:November 2008

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A Multi-Center Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase IIb Proof of Concept Study With 3 Oral Groups of AZD3480 During 12 Weeks Treatment of Cognitive Deficits in Patients With Schizophrenia

The purpose of this study is to demonstrate that AZD3480 improves cognition in patients with
stable schizophrenia who are being treated with an atypical antipsychotic and who are active
cigarette smokers, to assess the safety and tolerability of AZD3480 and to define the optimal
dose(s) to be used in future trials.


Inclusion Criteria:

- Diagnosis of schizophrenia

- Outpatient at the time of screening and randomization

- Stable housing defined as having a place to live in the community (ie, not in a
hospital or nursing home)

- Active cigarette smoking (10 or more cigarettes per day

Exclusion Criteria:

- Any significant psychiatric or neurological disease other than schizophrenia, or
current diagnosis of major depressive disorder

- Known or suspected drug or alcohol abuse within the 6 months or urine toxicology test
positive for illegal or non-prescribed substances

- Impaired vision and/or hearing making cognitive testing difficult
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