Study Of GW679769 In Major Depressive Disorder

Inclusion criteria:

- Subjects must have the ability to comprehend the key components of the consent form.

- Subject must have met DSM-IV-TR (Diagnostic and Statistical Manual of Mental
Disorders, Fourth Edition, Text Revision) criteria for current MDE (major depressive
episode) for at least 8 weeks prior to the Screening Visit.

- If female, subjects must be practicing an acceptable method of birth control.

- Subjects must have rating scores as outlined.

Exclusion criteria:

- Subjects whose symptoms of the MDE are better accounted for by another diagnosis.

- Subjects with a history of schizophrenia, schizoaffective disorders or bipolar
disorder.

- Subjects have a positive urine test for illicit drug use and/or a history of substance
abuse or alcohol dependence within the past 12 months.

- Subjects with an unstable medical disorder.

- If female, pregnant or lactating.

- Subjects who have received ECT (electroconvulsive therapy) or TMS (transcranial
magnetic stimulation) within the 6 months preceding screening or who have ever been
homicidal.