Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial

The goal of this project is to assess repeated and ongoing oral care and the way it may
affect inflammation and quality of life in hemodialysis patients. Two treatment groups will
be compared:

- 1) ongoing and repeated gum disease therapy including deep tooth cleaning followed by
multiple appointments of maintenance

- 2) single session of gum disease therapy with only one session of deep tooth cleaning
Samples of blood will be obtained for study to examine the changes of inflammatory
substances in the blood as a result of the two different gum disease treatments. Also, a
14-question survey will be discussed with you to assess oral health related quality of
life (OHIP-14) and the way it is affected by oral care.

For this project, four dialysis centers will be randomly assigned to either of the treatment
groups #1 or #2 prior to your enrollment. For this purpose, there are two distinct consent
forms explaining the visits, procedures and risks of the two treatment groups #1 or #2. As a
result, all participants in the same dialysis center will belong to the same treatment group
(either #1 or #2) and presented with the corresponding consent form.

This dialysis center has been randomized to treatment group # 1; therefore you will receive
ongoing and repeated gum disease therapy including deep tooth cleaning followed by multiple
appointments of maintenance.