Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 50 - 79 |
| Updated: | 4/17/2018 |
| Start Date: | September 25, 2017 |
| End Date: | August 1, 2020 |
| Contact: | Daniel H Craighead, PhD |
| Email: | daniel.craighead@colorado.edu |
| Phone: | 303-492-4568 |
The purpose of this study is to assess the efficacy of inspiratory muscle strength training
for lowering blood pressure and improving physiological function (vascular, motor, and
cognitive) in middle-aged and older adults with elevated systolic blood pressure.
for lowering blood pressure and improving physiological function (vascular, motor, and
cognitive) in middle-aged and older adults with elevated systolic blood pressure.
Over, the proposed research project has the long-term potential to influence clinical
practice by establishing a novel lifestyle intervention for treating multiple domains of age-
and hypertension-associated physiological dysfunction and thereby reducing the risk of
clinical disease and disability.
practice by establishing a novel lifestyle intervention for treating multiple domains of age-
and hypertension-associated physiological dysfunction and thereby reducing the risk of
clinical disease and disability.
Inclusion Criteria:
- Ability to provide informed consent
- Willing to accept random assignment to condition
- Women will be confirmed as postmenopausal (either natural or surgical) based on
cessation of menses for >1 year.
- Resting systolic blood pressure 120-159 mmHg
- Resting diastolic blood pressure <100 mmHg
- Subjects taking anti-hypertensive medications will be included provided they meet the
other inclusion criteria, including elevated systolic blood pressure. These
medications will not be withheld prior to experimental protocols.
- Free from alcohol dependence or abuse, as defined by the American Psychiatry
Association, Diagnostic and Statistical Manual or Mental Disorders (DSM-IV)
Exclusion Criteria:
- Current smoking
- Chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome,
coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney
disease requiring dialysis, neurological disorders or diseases that may affect
motor/cognitive function [multiple sclerosis, Parkinson's disease, polio, Alzheimer's
disease, dementia, or other brain diseases of aging]), except hypertension
- Postmenopausal <1 year
- Scoring <21 on the mini-mental state examination
- Moderate or sever peripheral artery disease (ankle-brachial index 0.7)
- Taking a medication that your doctor deems unsafe to hold for >1 week
- A graded exercise test will be performed by all subjects. If there is physician
concern or an adverse event, the subject will not participate in the study.
- No weight stable in the prior 3 months (>2 kg weight change) or unwilling to remain
weight stable throughout study (rationale: recent weight change or weight loss can
influence vascular function)
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