A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation



Status:Recruiting
Conditions:Hospital, Pulmonary, Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases, Other
Healthy:No
Age Range:Any
Updated:9/27/2017
Start Date:September 19, 2017
End Date:October 31, 2018
Contact:Brittany L Duyka, MD
Email:Brittany.L.Duyka@uth.tmc.edu
Phone:(713) 500-5519

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Trial Summary
Trial Overview
Inclusion Criteria

A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation - a Feasibility Study

The purpose of this study is to determine if among infants <30 weeks gestational age on nasal
continuous positive airway pressure (NCPAP), whether discontinuing CPAP after gradual
reduction in continuous positive airway pressure (CPAP) pressure leads to successful weaning
off CPAP when compared to discontinuing CPAP without weaning pressure.


Inclusion Criteria:

- All infants < 30 weeks by dates, on NCPAP therapy, on caffeine 10mg/kg daily

- Meet CPAP stability criteria for ≥ 12hours (CPAP 6 cm H2O, FiO2 maintain sats 85-95%), Respiratory rate consistently less than 60, Mild to no
subcostal/intercostal retractions, No Apnea or bradycardia event that requires bag
mask ventilation, Less than 3 apnea/brady/desat episodes in any 1 hour period for
previous 6 hours, Tolerated time off CPAP during routine CPAP care (~15 min)

Exclusion Criteria:

- Major congenital anomalies including congenital heart disease

- Anomalies that prevent discontinuation of NCPAP

- Undergoing current evaluation for and/or treatment of sepsis
We found this trial at
1
site
University of Texas Health Science Center at Houston
7000 Fannin St
Houston, Texas 77030
(713) 500-4472
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
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from
Houston, TX
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