Paleolithic Diets vs T2D and Improvements in the Metabolic Syndrome

Therapuetic Areas:Endocrinology
Age Range:18 - Any
Start Date:September 2007
Contact:Shelley McCoy

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Paleolithic Diets and Metabolic Control in Type 2 Diabetes Mellitus

This study proposes to evaluate the physiological effects of eating Paleolithic type diet
("hunter-gatherer's diet") on Type 2 diabetic patients. The diet essentially consists of
fruits, vegetables, nuts, lean meats, excludes dairy products and grains.Subjects will be
randomized into taking either ADA (American Diabetic Association) recommended diet or
Paleolithic diet for 21 days. The research kitchen will provide all food items and total
calories in both groups will be adjusted to maintain baseline weight. Blood and urine test
will be done in the first 3 days, last 3 days and 1 month after the study period to study
and compare the effects of the two diets on subjects glucose control, lipid profile and
other parameters of cardiovascular physiology.

We hypothesize that a palaeolithic diet in subjects with Type 2 diabetes mellitis, will
result in improvement in above parameters and lead to improvement in glucose control with
less need for diabetes medicines (either lower doses or fewer medications) to a greater
extent than in subjects fed with ADA diet, without any change in weight. We also expect a
beneficial effect on blood vessel function, lipid profiles and blood pressure.

Inclusion Criteria:

- Type 2 diabetic patients

- Age >= 18 yrs

- BMI < 40 kg/m2

- Normal cardiac, renal and hepatic function

Exclusion Criteria:

- Subjects on thiazolidinediones ( Avandia, Actos) or other medications that
interfere with the testing procedures

- Subjects unwilling or unable to follow the diet specified

- Pregnant women

- Subjects who are unable to understand the consent form

- Hematocrit less than 30

- Patients with defibrillators
We found this trial at
533 Parnassus Ave
San Francisco, California 94122
(415) 476-9000
University of California - San Francisco The leading university exclusively focused on health, UC San...
San Francisco, CA
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