Proton Re-Irradiation for Recurrent Head and Neck Cancer



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:July 10, 2017
End Date:July 2020
Contact:Nancy Lee, MD
Email:leen2@mskcc.org
Phone:212-639-3341

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A Phase II Study of Proton Re-Irradiation for Recurrent Head and Neck Cancer

The purpose of this study is to evaluate the tumor control and the side effects of using
proton therapy for head and neck cancer that has come back.


Inclusion Criteria:

- Patient willing and able to provide written informed consent

- Age ≥18 years at the time of consent

- Pathologically confirmed diagnosis of a recurrent or a new primary head and neck
cancer

- A history of prior radiation to the head and neck (>/= 40 Gy, in 2 Gy/fraction
equivalent)

- The recurrent or the second primary tumor is unresectable, the patient elects against
surgical resection; patients who underwent surgery who has indications for
postoperative radiation therapy is also eligible

- Men and women of childbearing potential must be willing to consent to using effective
contraception while on treatment and for at least 3 months after treatment Note:
Patient with <6 months of life expectancy will be treated with palliative QUAD shot
radiotherapy and those with > 6 months of life expectancy will be treated with
conventionally fractionated full dose re-irradiation approach. Additional other
factors determining which patients will be treated with Quad Shot therapy rather than
full dose are if the patients have poor performance status, bulky or diffuse disease,
significant medical co-morbidities, and significant metastatic disease burden.

Exclusion Criteria:

- Women who are pregnant or lactating

- Inability to comply with study and/or follow-up procedures

- <6 months between completion of prior RT and initiation of reirradiation using proton
therapy
We found this trial at
8
sites
Commack, New York 11725
Phone: 212-639-3341
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136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
Phone: 212-639-3341
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Harrison, New York
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480 Red Hill Road
Middletown, New Jersey 07748
Phone: 212-639-3341
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225 Summit Avenue
Montvale, New Jersey 07645
Phone: 212-639-3341
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Nancy Lee, MD
Phone: 212-639-3341
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Rockville Centre, New York 11570
Phone: 212-639-3341
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Uniondale, New York 11553
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