Genetic Evaluation of Men (GEM)



Status:Recruiting
Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:11/23/2018
Start Date:October 23, 2014
End Date:January 2021
Contact:Giri Veda, M.D.
Phone:215-503-5285

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This is a prospective research registry and prospective genetic testing cohort study. The
goal is to collect personal medical and cancer history data, family cancer data, exposure
history, and biospecimens to support research focused on optimal genetic testing strategies
for men with prostate cancer with the ultimate goal of informing national guidelines focused
on genetic evaluation for prostate cancer.

Objectives:

1. Collect detailed family cancer histories, personal medical history, prostate cancer
clinical features, and exposure history from men with prostate cancer and men without
prostate cancer to support studies focused on identifying hereditary cancer syndromes
and genetic/epidemiologic factors predisposing to prostate cancer susceptibility.

2. Collect behavioral measures to support research focused on assessing the needs of men
undergoing cancer risk evaluation and satisfaction with the process.

3. Create and maintain a biospecimen bank with specimens from men with prostate cancer and
without prostate cancer to support studies focused on genetic alterations predisposing
to prostate cancer risk.

4. Perform targeted and broad-scale genetic and genomic sequencing to detect genetic
alterations related to prostate cancer risk.

5. Develop mechanisms to recontact participants with updates on research genetic results to
guide genetic testing for inherited prostate cancer risk.

Inclusion Criteria:

1. Men with a personal history of prostate cancer

2. Unaffected males who are at higher risk for prostate cancer

Exclusion Criteria:

1. Age < 18 years

2. Mental or cognitive impairment that interferes with ability to provide informed
consent

3. Social circumstances that may impair the ability to follow through with study or
provide informed consent (such as homelessness, drug/alcohol dependence, etc.)
We found this trial at
3
sites
Philadelphia, Pennsylvania 19107
Phone: 215-503-5285
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1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Principal Investigator: Mark Sundermeyer, MD
Phone: 215-481-2400
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Philadelphia, Pennsylvania 19111
Principal Investigator: Elias Obeid, MD, MPH
Phone: 888-369-2427
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