Exercise Regulation of Human Adipose Tissue

Inclusion Criteria:

- Age: 25-55 years old at the time of screening

- Body mass index (BMI) must be:

- ≥20 and ≤ 27 kg/m2 for lean subjects

- ≥25 and ≤ 27 kg/m2 for subjects with type 2 diabetes

- ≥27 and ≤ 37 kg/m2 for obese/overweight subjects

- HbA1c values:

- ≤5.7 ± 0.1% for lean and overweight/obese subjects

- 6.5 ± 0.1% - 9.0 ± 0.1% for subjects with type 2 diabetes

Exclusion Criteria:

- Age <25 and >55 years old

- Type 1 Diabetes

- HbA1c ≥ 9.0%

- Heart or lung disease

- Basal-Bolus Insulin regimen

- Use of beta-blockers or thiazolidinediones

- Acute systemic infection accompanied by fever, body aches, or swollen lymph glands

- BMI ≥ 37 kg/m2

- Current dieting or weight loss efforts

- Current pregnant or breastfeeding

- Known history of HIV/AIDS or certain cancers

- Biochemical evidence of renal or hepatic dysfunction; renal or liver disease

- Demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis

- Recent blood donation

- Clinical history of stroke

- Severe hypertension (systolic > 160 mmHg or diastolic > 90 mmHg)

- Inability to exercise at 50% of predicted heart rate (HR) reserve at baseline

- Participants who screen positive for The American Heart Association's
contraindications to exercise testing

- History of keloid formation