Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)



Status:Recruiting
Conditions:Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/21/2019
Start Date:October 9, 2017
End Date:July 26, 2023
Contact:Toll Free Number
Email:Trialsites@merck.com
Phone:1-888-577-8839

Use our guide to learn which trials are right for you!

A Phase III, Randomized, Double-Blind, Clinical Trial of Pembrolizumab (MK-3475) Plus Chemotherapy (XP or FP) Versus Placebo Plus Chemotherapy (XP or FP) as Neoadjuvant/Adjuvant Treatment for Subjects With Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma (KEYNOTE-585)

The purpose of this study is to evaluate the efficacy of pembrolizumab (MK-3745) in the
neoadjuvant (prior to surgery) or adjuvant (after surgery) treatment of previously untreated
adults with gastric and gastroesophageal junction (GEJ) adenocarcinoma.

The primary hypotheses of this study are that pembrolizumab plus chemotherapy is superior to
placebo plus chemotherapy in terms of overall survival (OS), event-free survival (EFS) and
pathological complete response (pathCR) rate.


Inclusion Criteria:

- Has previously untreated localized gastric or GEJ adenocarcinoma as defined by T3 or
greater primary lesion or the presence of any positive nodes - N+ (clinical nodes)
without evidence of metastatic disease.

- Plans to proceed to surgery following pre-operative chemotherapy based on standard
staging studies per local practice.

- Is willing to provide tissue from a tumor lesion at baseline and at time of surgery.

- Has an Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 1
within 3 days prior to the first dose of study treatment.

- Has adequate organ function.

- Male participants of childbearing potential must agree to use an adequate method of
contraception for the course of the study through 180 days after the last dose of
chemotherapy.

- Female participants of childbearing potential must be willing to use an adequate
method of contraception for the course of the study through 180 days after the last
dose of chemotherapy or through 120 days after the last dose of pembrolizumab,
whichever is greater.

- Has life expectancy of greater than 6 months.

Exclusion Criteria:

- Has a history of (non-infectious) pneumonitis that required steroids or has current
pneumonitis.

- Has an active infection requiring systemic therapy.

- Is currently participating in or has participated in a trial of an investigational
agent or has used an investigational device within 4 weeks prior to the first dose of
study treatment.

- Has received prior therapy with an anti-programmed cell death protein-1 (anti-PD-1),
anti-programmed cell death-ligand 1 (anti-PD-L1), or anti-PD-L2 agent or with an agent
directed to another stimulatory or co-inhibitory T-cell receptor (i.e., cytotoxic
T-lymphocyte-associated protein 4 [CTLA-4], tumor necrosis factor receptor superfamily
member 4 [OX-40], necrosis factor receptor superfamily member 9 [CD137]) or has
previously participated in a Merck pembrolizumab (MK-3475) clinical trial.

- Has received prior systemic anti-cancer therapy including investigational agents for
the current malignancy.

- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 14 days prior the first dose of study treatment.

- Has a known additional malignancy that is progressing or has required active treatment
within the past 5 years. Note: Participants with basal cell carcinoma of the skin,
squamous cell carcinoma of the skin, or carcinoma in situ that have undergone
potentially curative therapy are not excluded.

- Has a known severe hypersensitivity (≥ Grade 3) to pembrolizumab, its active substance
and/or any of its excipients, or to any of the study chemotherapy agents and/or to any
of their excipients.

- Has an active autoimmune disease that has required systemic treatment in past 2 years.

- Has a known history of human immunodeficiency virus (HIV) infection.

- Has a known history of Hepatitis B or known active Hepatitis C virus infection.

- Has a known history of active tuberculosis (TB).

- Female participants who are pregnant or breastfeeding or expecting to conceive
children within the projected duration of the study, starting with the screening visit
through180 days after the last dose of chemotherapy or through 120 days after the last
dose of pembrolizumab, whichever is greater.

- Male participants who are expecting to father children within the projected duration
of the study, starting with the screening visit through 180 days after the last dose
of chemotherapy.

- Has had an allogenic tissue/solid organ transplant.

- Has received a live vaccine within 30 days prior to the first dose of study treatment.
We found this trial at
15
sites
Philadelphia, Pennsylvania 19111
Phone: 215-214-4283
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Phone: 877-275-7724
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Phone: 703-280-5390
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
Brussels,
Phone: +3225417209
?
mi
from
Brussels,
Click here to add this to my saved trials
Chicago, Illinois 60611
Phone: 312-695-6180
?
mi
from
Chicago, IL
Click here to add this to my saved trials
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Phone: 773-702-7596
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Duarte, California 91010
Phone: 626-471-9200
?
mi
from
Duarte, CA
Click here to add this to my saved trials
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Phone: 703-280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
?
mi
from
Fairfax, VA
Click here to add this to my saved trials
333 Cedar Street
New Haven, Connecticut 06520
(203) 785-4095
Phone: 203-785-6661
Yale Cancer Center Yale Cancer Center combines a tradition of innovative cancer treatment and quality...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
160 East 34th Street
New York, New York 10016
Phone: 202-444-1781
?
mi
from
New York, NY
Click here to add this to my saved trials
New York, New York 10065
Phone: 646-962-6200
?
mi
from
New York, NY
Click here to add this to my saved trials
New York, New York 10065
Phone: 646-888-4183
?
mi
from
New York, NY
Click here to add this to my saved trials
3401 N Broad St
Philadelphia, Pennsylvania
(215) 707-2000
Phone: 215-214-4283
Temple University Hospital On January 18, 1892 a three-story house at 3403 North Broad Street...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Salt Lake City, Utah 84112
Phone: 585-275-5823
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
3700 O St NW
Washington, District of Columbia 20057
(202) 687-0100
Phone: 801-585-0330
Georgetown University Georgetown University is one of the world's leading academic and research institutions, offering...
?
mi
from
Washington,
Click here to add this to my saved trials