A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Patients With Advanced Solid Tumors



Status:Recruiting
Conditions:Colorectal Cancer, Cancer, Cancer, Cancer, Pancreatic Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:August 4, 2017
End Date:December 20, 2021
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information.
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 1b/2 Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Patients With Advanced Solid Tumors

This study will evaluate the safety profile, tolerability, PK, PD, and preliminary efficacy
of BMS-813160 alone or in combination with either chemotherapy or nivolumab in participants
with metastatic colorectal and pancreatic cancers.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Participants must have metastatic colorectal or pancreatic cancer

- Eastern Cooperative Oncology Group (ECOG) performance status of ≤1

- Ability to swallow pills or capsules

- All participants will be required to undergo mandatory pre and on-treatment biopsies

- Adequate marrow function

- Adequate other organ functions

- Ability to comply with study visits, treatment, procedures, PK and PD sample
collection, and required study follow-up

Exclusion Criteria:

- Histology other than adenocarcinoma (neuroendocrine or acinar cell)

- Suspected, known, or progressive CNS metastases (Imaging required only if participants
are symptomatic)

- Participants with active, known or suspected autoimmune disease

- Participants with a condition requiring systemic treatment with either corticosteroids
(> 10 mg daily prednisone equivalents) or other immunosuppressive medications within
14 days of study treatment administration

- Interstitial lung disease that is symptomatic or may interfere with the detection or
management of suspected treatment-related pulmonary toxicity

- Prior treatment with CCR2 and/or CCR5 inhibitors, PD-1, PD(L)-1 or CTLA-4 antibodies

- History of allergy to study treatments or any of its components of the study arm that
participant is enrolling

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
27
sites
Boston, Massachusetts 02111
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Phone: 443-287-0002
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Phone: 205-975-0960
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Phone: 585-276-4447
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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Allentown, Pennsylvania 18105
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Aurora, Colorado 80045
Phone: 720-848-4288
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Charleston, South Carolina 29425
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Charlotte, North Carolina 28203
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Charlotte, NC
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Charlottesville, Virginia 22908
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Charlottesville, VA
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2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Phone: 216-444-8258
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Cleveland, Ohio 44195
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Phone: 551-996-4725
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Hattiesburg, Mississippi 39401
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Houston, Texas 77030
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
Phone: 323-409-4368
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Malvern, Victoria
Phone: +61395083417
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Nashville, Tennessee 37203
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 646-888-4329
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Orange, California 92868
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Phone: 215-503-3367
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-220-9713
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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200 1st Street Southwest
Rochester, Minnesota 55905
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-747-3575
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Salt Lake City, Utah 84112
Phone: 803-587-4402
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Scottsdale, Arizona 85259
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 687-7695
Phone: 202-687-9782
Georgetown University Medical Center Georgetown University Medical Center is committed to excellence in research, education...
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