Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3



Status:Recruiting
Conditions:Parkinsons Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:22 - 85
Updated:6/23/2018
Start Date:June 19, 2018
End Date:March 2022
Contact:Michael C. Park, MD/PhD
Email:mcpark@umn.edu
Phone:6126264706

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Trial Summary
Trial Overview
Inclusion Criteria
This study will test the hypothesis that deep brain stimulation (DBS) targeting specific
changes in oscillatory activity at the site of stimulation will prove superior to continuous
isochronal DBS thus providing the rationale for development and optimization of closed loop
paradigms and determine whether the optimal closed-loop biomarker varies across subcortical
targets, is task dependent, or serves to re-establish a default network that removes an
underlying disruptive physiological state leading to greater improvement in motor signs and
task performance.


Inclusion Criteria:

- Diagnosis of idiopathic PD

- A history of a good response to levodopa (carbidopa/levodopa) defined as at least a
30% improvement in motor UPDRS score

- DBS surgery or IPG battery replacement at UMN is planned as part of routine clinical
care.

Exclusion Criteria:

- Other significant neurological disorder

- History of dementia

- Prior history of stereotactic neurosurgery

- Patients with post-operative complications or adverse effects (e.g. ON stimulation
dystonias) that affect patient safety or confound the experiment will be excluded from
further study

- Pregnant women
We found this trial at
1
site
University of Minnesota Medical Center
Minneapolis, Minnesota 55455
Phone: 612-626-4706
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Minneapolis, MN
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