Apolipoprotein E (ApoE) and Metabolism



Status:Recruiting
Conditions:Cognitive Studies, Cognitive Studies, Healthy Studies
Therapuetic Areas:Psychiatry / Psychology, Other
Healthy:No
Age Range:18 - 65
Updated:5/30/2018
Start Date:April 24, 2018
End Date:April 30, 2020
Contact:Lance Johnson, PhD
Email:Johnson.Lance@uky.edu
Phone:8593232146

Use our guide to learn which trials are right for you!

APOE, Metabolism and Cognitive Function: An Assessment Via Indirect Calorimetry

Impaired metabolism and the gene apolipoprotein E (ApoE) are independent risk factors for
cognitive impairment and dementia. In humans, there are three major versions of apoE (E): E2,
E3, and E4. Some studies suggest that the different versions of apoE have varying effects on
whole body and brain metabolism. The goal of this project is to better understand the
relationship between apoE and metabolism. This will help investigators identify new targets
for the prevention and treatment of cognitive decline and dementia.

The investigator hopes determine whether a participant's version of ApoE affects their
metabolic rate at rest and during a cognitive challenge. To determine this, the investigator
will measure basal (resting) metabolic rates using a technique called indirect calorimetry
(IC). This is accomplished by wearing a loose-fitting face mask that measures oxygen intake
and carbon dioxide output.

To more accurately measure the amount of carbohydrates, fats and proteins that the body is
metabolizing, participants will be asked to provide two urine samples (one at the beginning,
and one at the end, of the study).

To determine what version of ApoE the participant inherited, the investigator will conduct a
genetic test on DNA isolated from the participant's blood.

Inclusion Criteria:

- all races/ethnicities

- ages 18-65

- cognitively normal

- good health

Exclusion Criteria:

- pregnant or breastfeeding.

- have a bleeding disorder,

- have a history of stroke, seizures, Parkinson's disease, history of head injury with
loss of consciousness, or other dementing disorder.

- have a history of alcoholism or drug abuse

- have a history of schizophrenia or currently suffer from bipolar disorder or major
depression.

- have vision or hearing loss severe enough to interfere with cognitive testing
We found this trial at
1
site
740 South Limestone Street
Lexington, Kentucky 40536
Phone: 859-323-2746
?
mi
from
Lexington, KY
Click here to add this to my saved trials