Mobile-Based Application "MyChoices"

"MyChoices", an app adapted from HealthMindr and developed using iterative feedback from
youth, is being refined to to maximize acceptability among YMSM. "MyChoices" was guided by
the Social Cognitive Theory (SCT) model and includes three major functions that are designed
to promote self-efficacy, self-regulation, goal-setting and environmental influences in order
to impact behavior change. (1) Tracking and Self-Monitoring HIV Risk: In order to target
self-regulation, brief surveys within the app are used to assess behavioral patterns of YMSM,
particularly around sexual relationships, which are then used to help customize the app for
each user. (2) HIV and sexually transmitted infection (STI) Prevention Information: In order
to improve self-efficacy for HIV testing and HIV prevention overall, quizzes and infographics
that appeal to YMSM have been incorporated into the app, focusing on promotion of HIV
prevention and regular HIV testing. The app also allows users to order OraQuick HIV home
testing kits and STI home collection kits (for rectal and urethral gonorrhea and Chlamydia
and syphilis). Additionally, the app includes information on testing sites and local PrEP
clinics (e.g., telephone, address, hours of testing, etc), and external links to specific
site webpages that are near the user (determined using GPS technology). (3) HIV Testing Plan:
Acknowledging the central role of goal setting and environmental influences on health
behavior, the app allows users to create a HIV testing plan by allowing them to compare and
choose different screening options (e.g., home self-testing, antigen, rapid). Questions about
HIV transmission behaviors and testing history are then asked to create a tailored testing
plan. After a HIV testing plan is developed, users have the option to customize reminders for
the timeframe selected (e.g., user is pinged every 3 months as a reminder to get tested).
Users are able to select from a list of phrases or create their own to ensure privacy.
Moreover, geofencing technology allows users to be notified when in the vicinity of testing
locations, based on the Geo Positioning System (GPS) location, during the testing timeframe.

This study is part of the iTech NIH U19, which has an overall goal to develop innovative
technology-focused interventions addressing the HIV prevention and care continuum for youth.

Inclusion Criteria:

- No HIV test in the past 3 months (self-reported).

- Not known to be HIV-infected (self-reported).

- Not currently taking PrEP (self-report).

- Owns or leases a phone with Android platform (for Aims 2 and 3) or iOS platform (Aim 3
only), has an active data plan, and willing to download the MyChoices application.

- Willing to attend an in-person baseline study visit in Boston or the Bronx and
complete online follow-up visits.

- Able to understand, read, and speak English.

- Participants ages 15-18: self-report at least one episode of anal intercourse with a
male or transfemale partner during the last 6 months.

- Participants ages 19-24: self-report evidence of high risk for acquiring HIV infection
including at least one of the following:

1. at least one episode of condomless anal intercourse with an HIV-infected or
unknown HIV status male or transfemale partner during the last 6 months; or

2. anal intercourse with 2 or more male or transfemale sex partners during the last
6 months; or

3. exchange of money, gifts, shelter, or drugs for anal sex with a male or
transfemale partner during the last 6 months; or

4. sex with a male or transfemale partner and has had an STI during the last 6
months.

Exclusion Criteria:

- Any health condition that may interfere with participation or the ability to provide
informed consent, including any debilitating or life-threatening conditions.

- Prior enrollment in an HIV vaccine trial with receipt of experimental vaccine product
and evidence of vaccine-induced seropositivity.

- Known to be HIV-infected.

- Any medical, psychiatric, or social condition or other responsibilities that, in the
judgment of the investigator, would make participation in the study unsafe, complicate
interpretation of study outcome data, or otherwise interfere with achieving the study
objectives.