Safety and Efficacy Study of Filgotinib, GS-9876 and Tirabrutinib in Adults With Active Sjogren's Syndrome



Status:Active, not recruiting
Conditions:Rheumatology
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - 75
Updated:2/21/2019
Start Date:May 1, 2017
End Date:October 2019

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Phase 2, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of Filgotinib, GS-9876 and GS-4059 in Adult Subjects With Active Sjogren's Syndrome

The primary objective of this study is to assess the efficacy of filgotinib, GS-9876, and
tirabrutinib (formerly GS-4059) in adults with active Sjogren's Syndrome (SjS).


Key Inclusion Criteria:

- Diagnosed with SjS according to American European Consensus Group (AECG)
classification

- Active SjS as defined by an ESSDAI ≥ 5

- Seropositivity for antibodies to SjS-associated antigens A and B (anti-SSA or
anti-SSB)

Key Exclusion Criteria:

- Concurrent treatment with any biologic disease modifying antirheumatic drug (bDMARD)
(prior bDMARD treatment allowed with appropriate washout as per study protocol)

Note: Other protocol defined Inclusion/Exclusion criteria may apply.
We found this trial at
35
sites
Suncoast Clinical Research, Inc.
New Port Richey, Florida 34652
?
mi
from
New Port Richey, FL
Click here to add this to my saved trials
Clinical Research of West Florida
2147 Northeast Coachman Road
Clearwater, Florida 33765
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Albuquerque Clinical Trials
Albuquerque, New Mexico
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Diagnostic Group Integrated Healthcare System, Pllc
3406 College Street
Beaumont, Texas 77701
?
mi
from
Beaumont, TX
Click here to add this to my saved trials
East Penn Rheumatology Associates, P.C.
Bethlehem, Pennsylvania 18015
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
Joint and Muscle Research Institute
Charlotte, North Carolina 28204
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
ClinSearch, LLC
Chattanooga, Tennessee 37421
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
Center for Arthritis and Rheumatic Diseases
Chesapeake, Virginia 23320
?
mi
from
Chesapeake, VA
Click here to add this to my saved trials
Medvin Clinical Research
Covina, California 91723
Phone: 626-869-5730
?
mi
from
Covina, CA
Click here to add this to my saved trials
Omega Research Consultants LLC
Debary, Florida
Phone: 386-668-4202
?
mi
from
Debary, FL
Click here to add this to my saved trials
Denver Arthritis Clinic
Denver, Colorado 80230
Phone: 303-394-2828
?
mi
from
Denver, CO
Click here to add this to my saved trials
Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
?
mi
from
Duncansville, PA
Click here to add this to my saved trials
Centrum Kliniczno-Badawcze
Elbl?g, 82300
?
mi
from
Elbl?g,
Click here to add this to my saved trials
Center for Arthritis and Osteoporosis
Elizabethtown, Kentucky 42701
?
mi
from
Elizabethtown, KY
Click here to add this to my saved trials
Center for Rheumatology, Immunology and Arthritis
Fort Lauderdale, Florida 33334
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
Accurate Clinical Research
Houston, Texas
?
mi
from
Houston, TX
Click here to add this to my saved trials
June D.O. PC
Lansing, Michigan 48910
?
mi
from
Lansing, MI
Click here to add this to my saved trials
North Georgia Rheumatology Group
Lawrenceville, Georgia 30046
?
mi
from
Lawrenceville, GA
Click here to add this to my saved trials
Wasatch Peak Family Practice
1580 Antelope Drive
Layton, Utah 84041
?
mi
from
Layton, UT
Click here to add this to my saved trials
Cape Fear Arthritis Care PLLC
1003 Olde Waterford Way
Leland, North Carolina 28451
?
mi
from
Leland, NC
Click here to add this to my saved trials
Physician Research Collaboration
Lincoln, Nebraska 68512
?
mi
from
Lincoln, NE
Click here to add this to my saved trials
Ramesh C. Gupta, M.D.
Memphis, Tennessee 38119
Phone: 901-681-9670
?
mi
from
Memphis, TN
Click here to add this to my saved trials
AARR Arizona Arthritis & Rheumatology Research
Mesa, Arizona 85202
?
mi
from
Mesa, AZ
Click here to add this to my saved trials
Southwest Rheumatology Research LLC
Mesquite, Texas 75150
?
mi
from
Mesquite, TX
Click here to add this to my saved trials
AARR Arizona Arthritis & Rheumatology Research
4550 East Bell Road
Phoenix, Arizona 85032
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Trinity Universal Research Associates, Inc.
Plano, Texas 75024
Phone: 214-726-6721
?
mi
from
Plano, TX
Click here to add this to my saved trials
IRIS Research and Development
Plantation, Florida
?
mi
from
Plantation, FL
Click here to add this to my saved trials
Clayton Medical Associates, P.C.
6400 Clayton Road
Saint Louis, Missouri 63117
Phone: 314-646-0688
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Pmg Research Of Salisbury
Salisbury, North Carolina 28144
Phone: 704-647-9913
?
mi
from
Salisbury, NC
Click here to add this to my saved trials
Arthritis Northwest
Spokane, Washington 99204
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Springfield Clinic
Springfield, Illinois 62703
Phone: 217-528-7541
?
mi
from
Springfield, IL
Click here to add this to my saved trials
North Mississippi Medical Clinics, Inc. - Clinical Research
Tupelo, Mississippi 38801
?
mi
from
Tupelo, MS
Click here to add this to my saved trials
Inland Rheumatology Clinical Trials, Inc.
Upland, California 91786
Phone: 909-296-8763
?
mi
from
Upland, CA
Click here to add this to my saved trials
Arthritis & Osteoporosis Clinic
Waco, Texas 76708
?
mi
from
Waco, TX
Click here to add this to my saved trials
Clinical Research Center of Reading, LLC
Wyomissing, Pennsylvania 19610
?
mi
from
Wyomissing, PA
Click here to add this to my saved trials