Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty

Three orthopedic surgeons will participate in the study (MBC, DJM, SAJ). The surgical
procedure will be performed as per each surgeon's routine practice. Patients will be asked to
ingest 20g of EAA or placebo two times a day between meals 1 week prior and 2 weeks
postoperatively. Patients will be given a pill organizer that has two doses per day with
either EAA or placebo. Thigh circumference will be measured at baseline, 2 weeks and 6 weeks
post-operatively. The mid-thigh measurement will be taken while the patient stands erect with
their feet slightly apart and their weight equally distributed. The girth measurement is
taken perpendicular to the long axis of the thigh. The tape measure will be placed at the
level midway between the trochanterion and tibiale laterale sites each time to ensure that
the same location is measured each time. The investigators will measure strength using a
handheld dynamometer and performing a straight leg raise and knee extension at 90 degrees on
the operative and the non-operative leg preoperatively, 2 weeks and 6 weeks post-operatively.
The medial and lateral epicondyles of the femur will be used to position the subject's knee
joint through the axis of rotation on the dynamometer. Strength will be tested at 30, 45 and
60 degrees of flexion. Physical activity will be collected using the Knee Society Score at
baseline and at 6 weeks postoperatively. After the trial is commenced, there will be no
additional enrollment once study numbers have been met.

Inclusion Criteria:

- All patients will be undergoing a primary unilateral total knee arthroplasty for a
diagnosis of osteoarthritis

Exclusion Criteria:

- All patients who were wheelchair bound preoperatively

- All patients who cannot participate in an outpatient physical therapy program for 3
days per week after surgery