Lipoic Acid for Progressive Multiple Sclerosis (MS)



Status:Recruiting
Conditions:Neurology, Neurology, Multiple Sclerosis
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 70
Updated:2/9/2019
Start Date:July 1, 2018
End Date:April 1, 2021
Contact:Cassidy A Taylor
Email:Cassidy.Taylor@va.gov
Phone:(503) 220-8262

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Lipoic Acid for the Treatment of Progressive Multiple Sclerosis

The purpose of the study is to determine if lipoic acid can preserve mobility and protect the
brain in progressive forms of multiple sclerosis.

This two-year study will determine if daily oral intake of lipoic acid will prove superior to
placebo in reducing injury to the brain and maintaining mobility in progressive MS. Mobility
will be assessed with the timed 25-foot walk test and 2-minute timed walk test as well as
fall counts. Neuroprotection will be measured by the extent of brain volume loss seen on MRI.

Inclusion Criteria:

- Diagnosis of progressive MS as defined by the study

- Able to give informed consent and to adhere to study procedures.

- Expanded Disability Status Scale (EDSS) 3.0 - 6.5: ambulatory for at least 20 meters
without rest and use of bilateral aids (canes, crutches, walker) or better.

Exclusion Criteria:

- A self-reported medical or neurological problem other than MS that is a cause of
progressive or fluctuating gait dysfunction

- Unable to undergo MRI

- Unable to follow directions in English as standardized scales are not all validated in
other languages.

- Current major disease or disorder other than MS (e.g., cancer, renal disease,
end-stage cardiopulmonary disease, post-traumatic stress disorder, etc.) that may
interfere with study procedures.

- Current Grade 1 or greater abnormal creatinine or glomerular filtration rate (GFR)
<55.

- Pregnant or breast-feeding.

- Insulin-dependent diabetes or diabetes not controlled on oral diabetes medications.

- Scheduled (every 3 months or more frequently) IV or oral steroids in the year prior to
enrolment.

- IV or oral steroids in the 60 days prior to enrolment.

- Use of LA in the prior 2 years exceeding the equivalent of 1200mg daily for 3 months.

- Participation in the pilot LA in SPMS trial.
We found this trial at
9
sites
Seattle, Washington 98108
Phone: 800-329-8387
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Phone: 205-934-1885
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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85 S Prospect St
Burlington, Vermont 5405
(802) 656-3131
Phone: 802-847-6039
University of Vermont The University of Vermont combines faculty-student relationships most commonly found in a...
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Burlington, VT
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201 Presidents Circle
Salt Lake City, Utah 84108
801) 581-7200
Phone: 801-587-3864
University of Utah Research is a major component in the life of the U benefiting...
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Ottawa, Ontario K1Y 4M9
Phone: 613-737-8104
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Portland, Oregon 97201
Principal Investigator: Rebecca I. Spain, MD MSPH
Phone: 503-418-2141
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Portland, OR
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Salt Lake City, Utah 84148
Phone: 323-442-5814
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5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Phone: 206-320-7115
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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Washington, District of Columbia 20422
Phone: 202-745-8000
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Washington,
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