Neuroimaging Studies of Practice and Smoking

The study is comprised of two parts: a pilot to test procedures to be used in the study,
followed by the study. The pilot phase of this study will enroll 30 participants. The main
study will enroll 80 after the pilot phase is completed. The pilot phase includes all of the
same procedures as the main study.

Inclusion Criteria:

- Smoke > 10 cigarettes per day for the last 6 months

- Smokes first cigarette within 60 minutes after waking

- Vision should be normal or corrected-to-normal (to ensure that they can accurately
see the images on the screen and select the appropriate response)

- Willing to complete all appointments and change smoking behaviors for 2 weeks

- No quit attempts or attempts to cut back in the last 30 days

- No plans to quit in the next 30 days

- High school graduate or GED

Exclusion Criteria:

- Serious medical illness unsuitable for the MR scanner based on best clinical judgment

- Any neurologic or psychiatric disorder except depression, anxiety (including
post-traumatic stress disorder), or attention-deficit disorder/attention-deficit
hyperactivity disorder

- Currently taking anti-seizure medication

- History of concussion

- Body mass index (BMI) over 50

- Left-handedness

- History of alcohol or other substance dependence or current abuse;

- Risk for hazard due to magnetic fields such as metal in the body surgically or
accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular
stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted
in their body, etc)

- Pregnancy