A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults



Status:Completed
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 75
Updated:1/19/2019
Start Date:May 6, 2017
End Date:August 2, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Dose-finding Study to Evaluate the Change in Weight After 24 Weeks Treatment With 8 Doses of LIK066 Compared to Placebo in Obese or Overweight Adults, Followed by 24 Weeks Treatment With 2 Doses of LIK066 and Placebo

This is a dose-finding study to evaluate the change in weight after 24 weeks treatment with 8
different doses of LIK066 compared to placebo in obese or overweight adults, followed by 24
weeks treatment with 2 doses of LIK066 and placebo.


Inclusion Criteria:

1. informed consent

2. (BMI>=30) or (BMI>=27 with history of CV disease, hypertension, dyslipidemia,
pre-diabetes or type 2 diabetes mellitus, sleep-apnea syndrome)

3. willing to comply with life-style intervention and treatment during the full duration
of the study (approximately 54 weeks)

Exclusion Criteria:

- Hypersensitivity to any of the study medications

- Pregnancy or lactating women

- History of malignancies

- Use of pharmacologically active weight loss products

- Bariatric surgery

- Ketoacidosis, lactic acidosis, hyperosmolar coma in the 6 months before the screening
visit.

- HbA1c >10% at the screening visit.
We found this trial at
56
sites
Novartis Investigative Site
Anniston, Alabama 36207
2117
mi
from 98109
Anniston, AL
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Athens, Georgia 30606
2214
mi
from 98109
Athens, GA
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Novartis Investigative Site
Augusta, Georgia 30904
2298
mi
from 98109
Augusta, GA
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Baltimore, Maryland 21287
2329
mi
from 98109
Baltimore, MD
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Novartis Investigative Site
Baton Rouge, Louisiana 70808
2031
mi
from 98109
Baton Rouge, LA
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Novartis Investigative Site
Beltsville, Maryland 20705
2323
mi
from 98109
Beltsville, MD
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Novartis Investigative Site
Beverly Hills, California 90211
959
mi
from 98109
Beverly Hills, CA
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Novartis Investigative Site
Bountiful, Utah 84010
695
mi
from 98109
Bountiful, UT
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Novartis Investigative Site
Bradenton, Florida 32405
2279
mi
from 98109
Bradenton, FL
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Novartis Investigative Site
Bronx, New York 10461
2405
mi
from 98109
Bronx, NY
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Novartis Investigative Site
Carmichael, California 95608
625
mi
from 98109
Carmichael, CA
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Novartis Investigative Site
Concord, California 94520
667
mi
from 98109
Concord, CA
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Novartis Investigative Site
Covington, Louisiana 70433
2073
mi
from 98109
Covington, LA
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Novartis
Denver, Colorado 80262
1023
mi
from 98109
Denver, CO
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Novartis Investigator Site
Evansville, Indiana 47713
1866
mi
from 98109
Evansville, IN
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Novartis Investigative Site
Fort Lauderdale, Florida 33313
2712
mi
from 98109
Fort Lauderdale, FL
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Novartis Investigative Site
Golden, Colorado 80401
1010
mi
from 98109
Golden, CO
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Novartis Investigative Site
Graz,
5416
mi
from 98109
Graz,
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Gurnee, Illinois 60031
1706
mi
from 98109
Gurnee, IL
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Novartis Investigative Site
Hammond, Louisiana 70403
2056
mi
from 98109
Hammond, LA
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Novartis Investigative Site
Hickory, North Carolina 28601
2238
mi
from 98109
Hickory, NC
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Honolulu, Hawaii 96813
2679
mi
from 98109
Honolulu, HI
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Houston, Texas 77030
1892
mi
from 98109
Houston, TX
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Novartis Investigative Site
Indianapolis, Indiana 46202
1867
mi
from 98109
Indianapolis, IN
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Novartis Investigative Site
Jasper, Alabama 35501
2044
mi
from 98109
Jasper, AL
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Novartis Investigative Site
Kenosha, Wisconsin 53144
1704
mi
from 98109
Kenosha, WI
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Lansdale, Pennsylvania 19446
2358
mi
from 98109
Lansdale, PA
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Los Angeles, California 90095
979
mi
from 98109
Los Angeles, CA
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Novartis Investigative Site
Louisville, Kentucky 40202
1938
mi
from 98109
Louisville, KY
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Metairie, Louisiana 70006
2090
mi
from 98109
Metairie, LA
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Missoula, Montana 59808
394
mi
from 98109
Missoula, MT
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Novartis Investigative Site
Moncks Corner, South Carolina 29461
2402
mi
from 98109
Moncks Corner, SC
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319, Novartis Investigational Site
Mount Pleasant, South Carolina 29464
2426
mi
from 98109
Mount Pleasant, SC
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Novartis Investigative Site
New Orleans, Louisiana 70115
2099
mi
from 98109
New Orleans, LA
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Novartis
230 Park Avenue, 21st Floor
New York, New York 10169
1-888-669-6682)
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
2400
mi
from 98109
New York, NY
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Newport News, Virginia 23606
2412
mi
from 98109
Newport News, VA
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Novartis Investigative Site
Northridge, California 91325
946
mi
from 98109
Northridge, CA
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Omaha, Nebraska 68144
1359
mi
from 98109
Omaha, NE
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Pittsburgh, Pennsylvania 15224
2134
mi
from 98109
Pittsburgh, PA
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Port Charlotte, Florida 33952
2589
mi
from 98109
Port Charlotte, FL
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Novartis Investigative Site
Renton, Washington 98055
11
mi
from 98109
Renton, WA
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Novartis Investigative Site
Richmond, Virginia 23249
2351
mi
from 98109
Richmond, VA
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Novartis Investigative Site
Roseville, California 95661
616
mi
from 98109
Roseville, CA
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Royal Oak, Michigan 48073
1922
mi
from 98109
Royal Oak, MI
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Saint Louis, Missouri 63128
1717
mi
from 98109
Saint Louis, MO
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Saint Peters, Missouri 63303
1695
mi
from 98109
Saint Peters, MO
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Salt Lake City, Utah 84103
701
mi
from 98109
Salt Lake City, UT
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San Ramon, California 94582
681
mi
from 98109
San Ramon, CA
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Springfield, Illinois 62703
1706
mi
from 98109
Springfield, IL
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Novartis Investigative Site
Stockton, California 95204
669
mi
from 98109
Stockton, CA
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Summerville, South Carolina 29485
2402
mi
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Summerville, SC
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Tacoma, Washington 98405
27
mi
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Tacoma, WA
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Towson, Maryland 21204
2323
mi
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Towson, MD
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Walnut Creek, California 94598
671
mi
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Walnut Creek, CA
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Wauconda, Illinois 60084
1698
mi
from 98109
Wauconda, IL
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West Palm Beach, Florida 33407
2688
mi
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West Palm Beach, FL
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