A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults



Status:Completed
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 75
Updated:1/19/2019
Start Date:May 6, 2017
End Date:August 2, 2018

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A Randomized, Double-blind, Dose-finding Study to Evaluate the Change in Weight After 24 Weeks Treatment With 8 Doses of LIK066 Compared to Placebo in Obese or Overweight Adults, Followed by 24 Weeks Treatment With 2 Doses of LIK066 and Placebo

This is a dose-finding study to evaluate the change in weight after 24 weeks treatment with 8
different doses of LIK066 compared to placebo in obese or overweight adults, followed by 24
weeks treatment with 2 doses of LIK066 and placebo.


Inclusion Criteria:

1. informed consent

2. (BMI>=30) or (BMI>=27 with history of CV disease, hypertension, dyslipidemia,
pre-diabetes or type 2 diabetes mellitus, sleep-apnea syndrome)

3. willing to comply with life-style intervention and treatment during the full duration
of the study (approximately 54 weeks)

Exclusion Criteria:

- Hypersensitivity to any of the study medications

- Pregnancy or lactating women

- History of malignancies

- Use of pharmacologically active weight loss products

- Bariatric surgery

- Ketoacidosis, lactic acidosis, hyperosmolar coma in the 6 months before the screening
visit.

- HbA1c >10% at the screening visit.
We found this trial at
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Athens, Georgia 30606
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Anniston, Alabama 36207
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Augusta, Georgia 30904
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Baltimore, Maryland 21287
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Baton Rouge, Louisiana 70808
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Beltsville, Maryland 20705
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Beverly Hills, California 90211
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Bountiful, Utah 84010
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Bradenton, Florida 32405
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Bronx, New York 10461
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Carmichael, California 95608
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Concord, California 94520
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Covington, Louisiana 70433
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Denver, Colorado 80262
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Evansville, Indiana 47713
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Fort Lauderdale, Florida 33313
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Golden, Colorado 80401
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Gurnee, Illinois 60031
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Hammond, Louisiana 70403
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Hickory, North Carolina 28601
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Honolulu, Hawaii 96813
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Houston, Texas 77030
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Indianapolis, Indiana 46202
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Jasper, Alabama 35501
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Kenosha, Wisconsin 53144
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Lansdale, Pennsylvania 19446
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Los Angeles, California 90095
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Louisville, Kentucky 40202
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Metairie, Louisiana 70006
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Missoula, Montana 59808
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Moncks Corner, South Carolina 29461
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Mount Pleasant, South Carolina 29464
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New Orleans, Louisiana 70115
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230 Park Avenue, 21st Floor
New York, New York 10169
1-888-669-6682)
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
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Newport News, Virginia 23606
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Northridge, California 91325
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Omaha, Nebraska 68144
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Pittsburgh, Pennsylvania 15224
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Port Charlotte, Florida 33952
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Renton, Washington 98055
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Richmond, Virginia 23249
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Roseville, California 95661
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Royal Oak, Michigan 48073
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Saint Louis, Missouri 63128
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Saint Peters, Missouri 63303
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Salt Lake City, Utah 84103
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San Ramon, California 94582
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Springfield, Illinois 62703
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Stockton, California 95204
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Summerville, South Carolina 29485
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Tacoma, Washington 98405
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Towson, Maryland 21204
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Walnut Creek, California 94598
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Wauconda, Illinois 60084
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West Palm Beach, Florida 33407
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