A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults



Status:Completed
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - 75
Updated:1/19/2019
Start Date:May 6, 2017
End Date:August 2, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Dose-finding Study to Evaluate the Change in Weight After 24 Weeks Treatment With 8 Doses of LIK066 Compared to Placebo in Obese or Overweight Adults, Followed by 24 Weeks Treatment With 2 Doses of LIK066 and Placebo

This is a dose-finding study to evaluate the change in weight after 24 weeks treatment with 8
different doses of LIK066 compared to placebo in obese or overweight adults, followed by 24
weeks treatment with 2 doses of LIK066 and placebo.


Inclusion Criteria:

1. informed consent

2. (BMI>=30) or (BMI>=27 with history of CV disease, hypertension, dyslipidemia,
pre-diabetes or type 2 diabetes mellitus, sleep-apnea syndrome)

3. willing to comply with life-style intervention and treatment during the full duration
of the study (approximately 54 weeks)

Exclusion Criteria:

- Hypersensitivity to any of the study medications

- Pregnancy or lactating women

- History of malignancies

- Use of pharmacologically active weight loss products

- Bariatric surgery

- Ketoacidosis, lactic acidosis, hyperosmolar coma in the 6 months before the screening
visit.

- HbA1c >10% at the screening visit.
We found this trial at
56
sites
Novartis Investigative Site
Northridge, California 91325
30
mi
from 91732
Northridge, CA
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Anniston, Alabama 36207
1838
mi
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Anniston, AL
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Novartis Investigative Site
Athens, Georgia 30606
1970
mi
from 91732
Athens, GA
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Novartis Investigative Site
Augusta, Georgia 30904
2057
mi
from 91732
Augusta, GA
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Novartis
Baltimore, Maryland 21287
2302
mi
from 91732
Baltimore, MD
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Novartis Investigative Site
Baton Rouge, Louisiana 70808
1585
mi
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Baton Rouge, LA
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Novartis Investigative Site
Beltsville, Maryland 20705
2287
mi
from 91732
Beltsville, MD
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Novartis Investigative Site
Beverly Hills, California 90211
21
mi
from 91732
Beverly Hills, CA
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Novartis Investigative Site
Bountiful, Utah 84010
578
mi
from 91732
Bountiful, UT
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Novartis Investigative Site
Bradenton, Florida 32405
1903
mi
from 91732
Bradenton, FL
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Bronx, New York 10461
2441
mi
from 91732
Bronx, NY
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Novartis Investigative Site
Carmichael, California 95608
364
mi
from 91732
Carmichael, CA
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Novartis Investigative Site
Concord, California 94520
350
mi
from 91732
Concord, CA
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Novartis Investigative Site
Covington, Louisiana 70433
1644
mi
from 91732
Covington, LA
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Novartis
Denver, Colorado 80262
820
mi
from 91732
Denver, CO
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Novartis Investigator Site
Evansville, Indiana 47713
1715
mi
from 91732
Evansville, IN
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Fort Lauderdale, Florida 33313
2309
mi
from 91732
Fort Lauderdale, FL
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Golden, Colorado 80401
807
mi
from 91732
Golden, CO
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Novartis Investigative Site
Graz,
6130
mi
from 91732
Graz,
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Gurnee, Illinois 60031
1721
mi
from 91732
Gurnee, IL
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Hammond, Louisiana 70403
1623
mi
from 91732
Hammond, LA
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Hickory, North Carolina 28601
2068
mi
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Hickory, NC
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Honolulu, Hawaii 96813
2573
mi
from 91732
Honolulu, HI
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Houston, Texas 77030
1357
mi
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Houston, TX
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Indianapolis, Indiana 46202
1792
mi
from 91732
Indianapolis, IN
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Jasper, Alabama 35501
1754
mi
from 91732
Jasper, AL
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Kenosha, Wisconsin 53144
1727
mi
from 91732
Kenosha, WI
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Lansdale, Pennsylvania 19446
2367
mi
from 91732
Lansdale, PA
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Los Angeles, California 90095
25
mi
from 91732
Los Angeles, CA
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Louisville, Kentucky 40202
1812
mi
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Louisville, KY
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Metairie, Louisiana 70006
1647
mi
from 91732
Metairie, LA
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Missoula, Montana 59808
909
mi
from 91732
Missoula, MT
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Moncks Corner, South Carolina 29461
2174
mi
from 91732
Moncks Corner, SC
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319, Novartis Investigational Site
Mount Pleasant, South Carolina 29464
2188
mi
from 91732
Mount Pleasant, SC
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New Orleans, Louisiana 70115
1655
mi
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New Orleans, LA
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Novartis
230 Park Avenue, 21st Floor
New York, New York 10169
1-888-669-6682)
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
2435
mi
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New York, NY
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Newport News, Virginia 23606
2322
mi
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Newport News, VA
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Omaha, Nebraska 68144
1291
mi
from 91732
Omaha, NE
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Pittsburgh, Pennsylvania 15224
2121
mi
from 91732
Pittsburgh, PA
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Port Charlotte, Florida 33952
2181
mi
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Port Charlotte, FL
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Novartis Investigative Site
Renton, Washington 98055
951
mi
from 91732
Renton, WA
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Richmond, Virginia 23249
2267
mi
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Richmond, VA
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Novartis Investigative Site
Roseville, California 95661
369
mi
from 91732
Roseville, CA
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Royal Oak, Michigan 48073
1962
mi
from 91732
Royal Oak, MI
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Saint Louis, Missouri 63128
1562
mi
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Saint Louis, MO
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Saint Peters, Missouri 63303
1550
mi
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Saint Peters, MO
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Salt Lake City, Utah 84103
570
mi
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Salt Lake City, UT
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San Ramon, California 94582
338
mi
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San Ramon, CA
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Springfield, Illinois 62703
1608
mi
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Springfield, IL
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Stockton, California 95204
326
mi
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Stockton, CA
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Summerville, South Carolina 29485
2167
mi
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Summerville, SC
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Tacoma, Washington 98405
939
mi
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Tacoma, WA
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Towson, Maryland 21204
2300
mi
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Novartis Investigative Site
Walnut Creek, California 94598
348
mi
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Walnut Creek, CA
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Wauconda, Illinois 60084
1708
mi
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Wauconda, IL
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West Palm Beach, Florida 33407
2300
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West Palm Beach, FL
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