Effects of Pregnenolone on Perceived Social Isolation
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 21 - 80 |
| Updated: | 11/30/2018 |
| Start Date: | May 1, 2017 |
| End Date: | June 1, 2019 |
| Contact: | Erika Kaske |
| Email: | ekaske@yoda.bsd.uchicago.edu |
| Phone: | 773-834-5264 |
Effects of Pregnenolone on Perceived Social Isolation: A Double-blind Randomized Electrical Neuroimaging Study
No studies to date have examined the effects of pregnenolone on hypervigilance for social
threat in individuals with perceived social isolation (PSI). We therefore are conducting a
double-blind randomized research study combining three validated behavioral paradigms on
social threat attention, perception of others, and emotion regulation with high-density
electrical neuroimaging to probe the neuro-circuitry of social threat processing in young
adults high in perceived social isolation two hours after the oral administration of 175mg
pregnenolone (N = 24), 400mg of pregnenolone (N = 24), or placebo (N = 24). Such research has
the potential to yield important insights into the neurobehavioral mechanisms of pregnenolone
on hypervigilance for social threat and perception of others--- a first key step toward the
development of adjunctive pregnenolone therapy in individuals with PSI.
threat in individuals with perceived social isolation (PSI). We therefore are conducting a
double-blind randomized research study combining three validated behavioral paradigms on
social threat attention, perception of others, and emotion regulation with high-density
electrical neuroimaging to probe the neuro-circuitry of social threat processing in young
adults high in perceived social isolation two hours after the oral administration of 175mg
pregnenolone (N = 24), 400mg of pregnenolone (N = 24), or placebo (N = 24). Such research has
the potential to yield important insights into the neurobehavioral mechanisms of pregnenolone
on hypervigilance for social threat and perception of others--- a first key step toward the
development of adjunctive pregnenolone therapy in individuals with PSI.
Inclusion Criteria:
- Age 21-80
- At least a score of 42 on the UCLA Loneliness scale.
- Right handed
- Normal or corrected eye sight
Exclusion Criteria:
- Medical history of cancer
- Steroid use
- Psychotropic drugs
- History of heart irregularities
- Have a counter indication to EEG
- Age <21 or >32
- Score less than 42 on UCLA loneliness scale
- Left handed
- Meet MINI criteria for anything but untreated major depressive disorder
- Uncorrected vision
- Current or past neurological disorder including epilepsy or traumatic brain injury
- Have a counter indication to electrical neuroimaging
- Under hormonal therapy (including, but not limited to, testosterone)
- Unstable mental illness
- History of bipolar disorder, schizophrenia, or psychotic disorder
- Current or recent (past 3 months) substance use or dependence
- Currently taking any medications that may have unfavorable interactions with
pregnenolone
We found this trial at
1
site
5801 South Ellis Avenue
Chicago, Illinois 60637
Chicago, Illinois 60637
773.702.1234
Principal Investigator: Stephanie Cacioppo, PhD
Phone: 773-834-5264
University of Chicago One of the world's premier academic and research institutions, the University of...
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