The Pathogenesis of OSA in People Living With HIV
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies, HIV / AIDS, Pulmonary |
| Therapuetic Areas: | Immunology / Infectious Diseases, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 40 - 79 |
| Updated: | 5/6/2017 |
| Start Date: | February 9, 2017 |
| End Date: | December 2018 |
| Contact: | Robert L Owens, M.D. |
| Email: | rowens@ucsd.edu |
| Phone: | (858) 657-5258 |
The purpose of this study is to help us understand how HIV and/or Anti-Retroviral Therapy
(ART) may predispose individuals to Obstructive Sleep Apnea (OSA). The traditional risk
factors for OSA are weight and age. However, people living with HIV on ART seem to have OSA
even when they are thin and young. The study involves a detailed physiological sleep study
and an MRI of the head and neck to understand the underlying cause of OSA in those with and
without HIV.
(ART) may predispose individuals to Obstructive Sleep Apnea (OSA). The traditional risk
factors for OSA are weight and age. However, people living with HIV on ART seem to have OSA
even when they are thin and young. The study involves a detailed physiological sleep study
and an MRI of the head and neck to understand the underlying cause of OSA in those with and
without HIV.
Participants who have sleep apnea and are using positive airway pressure (PAP) with and
without HIV will be enrolled if they otherwise meet all the inclusion criteria, and none of
the exclusion criteria.
Subjects will undergo two overnight sleep studies (polysomnograms, PSGs) and a MRI scan of
the upper airway. The first sleep study will evaluate the severity of sleep disordered
breathing and will be identical to a clinical PSG. The second sleep study will measure the
physiological traits most important for OSA, such as upper airway anatomy, control of
breathing, sleep stability, and upper airway muscle activation. These measurements are
performed while subjects sleep using PAP, but the PAP level is adjusted during the night,
and the subject's response is measured. The MRI scan will be of the head and neck and will
occur during the evening time. Subjects will be encouraged to sleep during this portion of
the study, as well.
without HIV will be enrolled if they otherwise meet all the inclusion criteria, and none of
the exclusion criteria.
Subjects will undergo two overnight sleep studies (polysomnograms, PSGs) and a MRI scan of
the upper airway. The first sleep study will evaluate the severity of sleep disordered
breathing and will be identical to a clinical PSG. The second sleep study will measure the
physiological traits most important for OSA, such as upper airway anatomy, control of
breathing, sleep stability, and upper airway muscle activation. These measurements are
performed while subjects sleep using PAP, but the PAP level is adjusted during the night,
and the subject's response is measured. The MRI scan will be of the head and neck and will
occur during the evening time. Subjects will be encouraged to sleep during this portion of
the study, as well.
Inclusion Criteria:
- Men and women with physician-diagnosed OSA who have been prescribed CPAP Ages >= 40
years old
- BMI 20 - 35 kg/m2
- For HIV group: physician diagnosis of HIV and viral suppression
Exclusion Criteria:
- Not compliant with CPAP (by Medicare criteria, e.g. ≥4 hours per night on 70% of
nights during a consecutive 30-day period via direct download or visual inspection of
usage data).
- Use of medication that affects the traits, e.g. narcotics or sedative-hypnotics
- Any cardiovascular, pulmonary or renal disease other than well controlled
hypertension or asthma.
- Pregnancy
- Currently smoking
- Any respiratory disorder other than OSA or well controlled asthma
- contraindication to MRI
We found this trial at
1
site
San Diego, California 92093
Principal Investigator: Robert L Owens, MD
Phone: 858-657-5258
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