General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:9/22/2018
Start Date:January 2017
End Date:December 2020

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General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial: Pragmatic Randomized Trial of Propofol vs Volatile Inhalational Anesthesia

This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with
total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane,
or desflurane) during cancer surgery. The primary endpoint is all-cause mortality.


Inclusion Criteria:

- Patients with known or suspected cancer and scheduled to undergo any of the following
oncologic surgical procedures:

- Lobectomy or pneumonectomy

- Esophagectomy

- Radical (total) cystectomy

- Pancreatectomy

- Partial hepatectomy

- Hyperthermic intraperitoneal chemotherapy (HIPEC)

- Gastrectomy (subtotal or total)

- Cholecystectomy or bile duct resection

Exclusion Criteria:

- Age less than 18 years

- American Society of Anesthesiologist Class 5

- Projected life expectancy less than 30 days

- Known or suspected hypersensitivity to either propofol, e.g. egg or soy allergy, or
volatile general anesthetic agents

- Known or suspected history of malignant hyperthermia
We found this trial at
6
sites
270-05 76th Ave
New Hyde Park, New York 11040
(718) 470-7480
Principal Investigator: Sanjeev Ponnappan, MD
Long Island Jewish Medical Center Serving North Shore LIJ Health System employees and their families....
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New Hyde Park, NY
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601 Elmwood Avenue
Rochester, New York 14642
(585) 275-2100
Univ of Rochester Medical Center One of the nation's top academic medical centers, the University...
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Rochester, NY
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Albany, New York 12208
Principal Investigator: Yashar Ettekal, MD
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Albany, NY
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Buffalo, New York 14263
Principal Investigator: Timothy Quinn, MD
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Buffalo, NY
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1428 Madison Ave
New York, New York 10029
(212) 241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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New York, NY
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Stony Brook, New York 11794
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Stony Brook, NY
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