Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:4/4/2019
Start Date:April 7, 2017
End Date:April 2019
Contact:Florence Grant, MD
Email:moses-gf@mskcc.org
Phone:212-639-8829

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Randomized Controlled Assessor Blinded Clinical Trial of Sugammadex Versus Neostigmine /Glycopyrrolate for Reversal of Rocuronium Induced Neuromuscular Blockade: Time to Discharge From Post Anesthesia Care Unit and Patient Satisfaction With Recovery

The purpose of this study is to compare two different medications (neostigmine/glycopyrrolate
and sugammadex) to see if one drug improves patient comfort regarding the return of muscle
strength after surgery.


Inclusion Criteria:

- Adult patients age 18 years of age or greater who are capable of giving consent

- Undergoing surgical procedures of expected length 6
Exclusion Criteria:

- Pregnancy

- History of documented anaphylaxis or contraindication to any of the study medications

- Active coronary disease with a positive cardiac stress test

- History of severe chronic obstructive pulmonary disease (COPD) defined as an FEV1 <
50% of predicted

- Serum Creatinine >/= 2.0 mg/dL

- Severe hepatic dysfunction accompanied by coagulopathy

- Definition:

- Known liver Disease AND

- INR > 1.5 (except for patients on anticoagulants) AND

- Platelet count <100,00/ul without other obvious cause

- Chronic sustained release opioid for > 2 weeks duration pre op (in the 30 days prior
to surgery)

- Use of toremifene

- Significant cognitive impairment or documented psychologic impairment

- Myasthenia gravis or other neuromuscular disease

- Patients who are not eligible for standard anesthetic induction, eg, those needing
rapid sequence induction or awake fiberoptic bronchial intubation.

- American Society of Anesthesiologists (ASA) Status > 3
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Harrison, New York
Phone: 212-639-8829
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136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
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650 Commack Rd
Commack, New York 11725
(631) 623-4000
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Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 212-639-8829
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