The STRIVE Study: Breast Cancer Screening Cohort
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/12/2019 |
| Start Date: | February 28, 2017 |
| End Date: | May 2025 |
The STRIVE Study: Breast Cancer Screening Cohort for the Development of Assays for Early Cancer Detection
GRAIL is using high-intensity sequencing of circulating cell-free nucleic acids (cfNAs) to
develop blood tests to detect cancer early. The purpose of this study is to train and
validate an assay to detect invasive breast cancer in patients undergoing mammography.
develop blood tests to detect cancer early. The purpose of this study is to train and
validate an assay to detect invasive breast cancer in patients undergoing mammography.
Detection of early stage cancer may be possible through analysis of circulating cell-free
nucleic acids (cfNAs) shed into the blood by tumors. GRAIL is using high-intensity sequencing
(based on broad genomic coverage and deep sequencing) of cfNAs, combined with machine
learning, to develop blood tests to detect cancer early. The purpose of this prospective,
multi-center, observational cohort study is to train and validate an assay for the early
detection of breast cancer. The study will collect blood samples from participants within 28
days of their screening mammogram. Additional blood samples will also be collected for a
subset of participants. For participants who receive a cancer diagnosis during the study,
tissue samples will be collected.
nucleic acids (cfNAs) shed into the blood by tumors. GRAIL is using high-intensity sequencing
(based on broad genomic coverage and deep sequencing) of cfNAs, combined with machine
learning, to develop blood tests to detect cancer early. The purpose of this prospective,
multi-center, observational cohort study is to train and validate an assay for the early
detection of breast cancer. The study will collect blood samples from participants within 28
days of their screening mammogram. Additional blood samples will also be collected for a
subset of participants. For participants who receive a cancer diagnosis during the study,
tissue samples will be collected.
Inclusion Criteria:
1. Women undergoing mammography for screening indications or have an appointment for
screening mammography.
2. Participant provides informed consent and expresses understanding of the protocol and
its requirements, risks, and discomforts.
Exclusion Criteria:
We found this trial at
37
sites
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Mayo Clinic Mayo Clinic's campus in Arizona provides medical care for thousands of people from...
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Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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701 East El Camino Real
Mountain View, California 94040
Mountain View, California 94040
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330 23rd Avenue North
Nashville, Tennessee 37203
Nashville, Tennessee 37203
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Menorah Medical Center Menorah Medical Center (MMC), a full-service, acute care hospital located on the...
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3883 Airway Drive, Suite 300
Santa Rosa, California 95403
Santa Rosa, California 95403
(707) 521-8830
Sutter Pacific Medical Foundation Sutter Pacific Medical Foundation doctors offer primary, specialty and complex medical...
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20201 North Scottsdale Healthcare Drive
Scottsdale, Arizona 85255
Scottsdale, Arizona 85255
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9220 East Mountain View Road
Scottsdale, Arizona 85258
Scottsdale, Arizona 85258
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