First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 127 |
| Updated: | 4/15/2017 |
| Start Date: | August 30, 2006 |
| End Date: | August 19, 2015 |
A Randomised, Double-blind, Multicentre Phase II/III Study to Compare the Efficacy of Cediranib (RECENTIN™, AZD2171) in Combination With 5-fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX), to the Efficacy of Bevacizumab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer
The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in
treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab)
in combination with FOLFOX.
treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab)
in combination with FOLFOX.
Inclusion Criteria:
- Clinical Diagnosis of colon or rectal cancer
- No prior systemic therapy for metastatic disease. Any adjuvant/neoadjuvant
oxaliplatin therapy must have been received >12 months prior to study entry and
adjuvant/neoadjuvant 5-FU must have been received >6 months prior to study entry.
Exclusion Criteria:
- Prior treatment with a VEGF Inhibitor, including bevacizumab and cediranib.
- Poorly controlled hypertension
We found this trial at
46
sites
Hilton Head Island, South Carolina 29926
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