Neuromodulation of Lidocaine and Capsaicin Cream Effects on Pain Experience

Conditions:Chronic Pain
Therapuetic Areas:Musculoskeletal
Age Range:21 - 50
Start Date:May 2016
End Date:May 2019
Contact:Georgia Wilson, BA

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Neuromodulation of Placebo and Nocebo Effects

The aim of this study is to use a brain stimulation tool called transcranial direct current
stimulation (tDCS) to investigate the analgesic (reducing sensitivity to pain) effects of
lidocaine cream and the hyperalgesic (increasing sensitivity to pain) effects of capsaicin
cream using a neutral cream as a control. tDCS stimulation has been shown to temporarily
influence the way the stimulated part of the brain functions. With this method, the
involvement of specific parts of the brain can be investigated in the working of the brain as
a whole.

Inclusion Criteria:

- Right handed healthy male and female adults aged 21-50

- No contraindications to fMRI scanning

- At least a 10th grade English-reading level; English can be a second language provided
that the patients feel they understand all the questions used in the assessment

Exclusion Criteria:

- Current or past history of major medical, neurological, or psychiatric illness

- Claustrophobia

- History of head trauma

- Instability of responses to experimental pain

- Non-fluent speaker of English

- Presence of any contraindications to fMRI scanning. For example: cardiac pacemaker,
metal implants, fear of closed spaces, pregnancy

- History of alcohol/substance abuse
We found this trial at
Charlestown, Massachusetts 02129
Principal Investigator: Jian Kong
Phone: 617-643-7947
Charlestown, MA
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