Ixekizumab in the Treatment of Bullous Pemphigoid

BP is the most common auto-immune blistering disease of the skin and causes significant
morbidity. BP disproportionally affects the elderly population and the current, non-specific
immunosuppressive therapies, in addition to patient comorbidities, are associated with a high
risk of infection related mortality. Neutrophils and their proteases have been shown to play
a major role in the cleavage of Bullous Pemphigoid 180 Antigen (BP180) in BP. Mast cells and
other cellular mediators also contribute to the pro-inflammatory environment within and
surrounding blisters of BP. However, the prior targeting of mast cells and basophils has
resulted in unpredictable disease control. Recently, IL-17 has been identified as a key
driver of chronic inflammation in BP. With the increasing aged population in the United
States, BP will increase in prevalence and the development of a more targeted approach will
be necessary to decrease morbidity and mortality. IL-17 inhibition with Ixekizumab may have
targeted, disease-modifying effects on BP. The primary objective is to test the effect of
Ixekizumab in the treatment of the autoimmune blistering disease, BP.

Subjects eligible for inclusion in this study have to fulfill all of the following
Inclusion criteria:

- Subjects must be able to understand and comply with the requirements of the study and
communicate with the investigator. Subjects must give written, signed, and dated
informed consent before any study related activity is performed. When appropriate, a
legal representative will sign the informed consent according to local laws and
regulation

- Both men and women must be at least 18 years of age at the time of screening

- Subjects must have clinical, histological, and serological features of BP

- Urticarial plaques and/or vesicles and bullae

- Characteristic eosinophilic spongiosis and/or subepidermal separation of the skin

- Positive direct immunofluorescence (IgG and or C3 at the basement membrane zone) or
indirect immunofluorescence (IgG on the roof of salt- split skin) or positive
serologies on ELISA for BPAG1 or BPAG2

- Subjects must have treatment naive BP or treatment refractory disease, as defined by
failure of at least one established treatment for BP

- Candidate for systemic therapy, defined by

- involvement of greater than 5 percent body surface area or moderate to extensive
disease as defined by: the mean number of new bullae and urticarial plaques that have
appeared over the course of 3 days as determined by the investigator or referring
physician (moderate disease defined by greater than 1 and less than 10 new bullae and
greater than 5 urticarial plaques and extensive disease by greater than 10 new bullae)

- Failure of prior therapy

- Topical treatment

- Systemic immunosuppressant

- Oral antibiotics and/or niacinamide

Exclusion Criteria:

Subjects fulfilling any of the following criteria are not eligible for inclusion in this
study. In order to ensure the recruitment of a representative sample of all eligible
subjects, the investigator may apply no additional exclusions.

- Forms of BP other than classic BP (e.g. mucous membrane BP, Brunsting-Perry BP, p200
BP, p105 BP, or BP with concomitant pemphigus vulgaris Drug-induced BP (e.g., new
onset or current exacerbation from angiotensin converting enzyme inhibitors,
penicillamine, furosemide, phenacetin)

- Subjects who are receiving treatments known to worsen BP and use of penicillamine or
phenacetin and those on angiotensin converting enzyme inhibitors or furosemide who
have not been on a stable dose at least 4 weeks prior to enrollment.

- Ongoing use of prohibited treatments.

- Previous exposure to Ixekizumab or any other biologic drug directly targeting IL-17A
or IL-17 (receptor A)RA

- Use of any other investigational drugs within 5 half-lives of the investigational
treatment before study drug initiation or until the pharmacodynamics effect has
returned to baseline, whichever is longer

- Previous use of IL-20 monoclonal antibody

- Pregnant or nursing (lactating) women (pregnancy is defined as the state of a female
after conception and until the termination of gestation, confirmed by a positive human
chorionic gonadotropin (hCG) laboratory test)

- Women of childbearing potential [Post-menopausal or not of child-bearing potential is
defined by: 1 year of natural (spontaneous) amenorrhea or Surgical bilateral
oophorectomy (with or without hysterectomy), total hysterectomy or tubal ligation at
least 6 weeks ago. Oophorectomy alone must confirmed by follow up hormone level
assessment to be considered not of child-bearing potential, defined as all women
physiologically capable of becoming pregnant, unless they are using basic methods of
contraception which includes:

- Total abstinence (Periodic abstinence and withdrawal are not acceptable methods of
contraception)

- Female sterilization (bilateral oophorectomy with or without hysterectomy), total
hysterectomy, or tubal ligation at least 6 weeks before taking study treatment.
Oophorectomy alone requires follow up hormone level assessment for fertility.

- Male sterilization (at least 6 months prior to screening). The vasectomized male
partner should be the sole partner for that subject.

- Barrier methods of contraception: condom or occlusive cap. Use of oral, injected or
implanted hormonal methods of contraception or other forms or hormonal contraception
that have complete efficacy (failure less than 1 percent). (The dose of the
contraceptive should be stable for 3 months)

- Active ongoing inflammatory diseases of the skin other than BP that might confound the
evaluation of the benefit of Ixekizumab

- Underlying condition (including, but not limited to metabolic, hematologic, renal,
hepatic, pulmonary, neurologic, endocrine, cardiac, infectious or gastrointestinal
conditions) which, in the opinion of the investigator, significantly immunocompromises
the subject and/or places the subject at unacceptable risk for receiving an
immunomodulatory therapy Investigator discretion should be used for subjects with
pre-existing or recent-onset central or peripheral nervous system demyelinating
disorders Significant medical problems, including but not limited to the following:
uncontrolled hypertension, congestive heart failure (New York Heart Association (NYHA)
status of class III or IV)

- Serum creatinine level exceeding 2.0 mg per dL (176.8 micro mol per L) at screening

- Total white blood cell (WBC) count less than 2,500 per microL, platelets less than
100,000 per microL, neutrophils less1500/microL or hemoglobin less than 8.5 g per dL,
at screening

- Active systemic infections during the 2 weeks prior to randomization (common cold
viruses not included) or any infection that reoccurs on a regular basis.

- Investigator discretion should be used regarding subjects who have traveled or resided
in areas of endemic mycoses, such as histoplasmosis, coccidioidomycosis or
blastomycosis and for subjects with underlying conditions that may predispose them to
infection, such as advanced or inadequately controlled diabetes. Due to its endemic
nature in Arizona, coccidioidomycosis screening is performed at baseline. A history of
a disseminated coccidioidomycosis infection will exclude subjects.

- History of an ongoing, chronic or recurrent infectious disease, or evidence of
tuberculosis infection as defined by a positive or indeterminate QuantiFERON
Tuberculosis (TB)-Gold test (QFT) at screening.

- Subjects with a positive QFT test may participate in the study if a full tuberculosis
work up (according to local practice/guidelines) is completed within 12 weeks prior to
establishes conclusively that the subject has no evidence of active tuberculosis.

If the presence of latent tuberculosis is established, then treatment must have been
initiated and maintained according to local country guidelines for at least 4 weeks prior
to randomization.

- Past medical history of, or current infection with, human immunodeficiency virus
(HIV), hepatitis B or hepatitis C prior to new diagnosis at screening

- History of lymphoproliferative disease and or any known malignancy and/or history of
malignancy of any organ system within the past 5 years

Exceptions include:

For skin squamous cell carcinoma in situ and or well differentiate squamous cell carcinoma
and/or basal cell carcinoma and or actinic keratosis and/or melanoma in situ that have been
treated with no evidence of recurrence For the cervix carcinoma that has been removed For
the colon non-invasive malignant colon polyps that have been removed

- Current severe progressive or uncontrolled disease which the investigator renders the
subject unsuitable for the trial or puts the subject at increased risk Inability or
unwillingness to undergo repeated venipuncture

- Any medical or psychiatric condition which, in the investigator's opinion, would keep
the subject from adhering to the protocol or completing the study per protocol

- History or evidence of ongoing alcohol or drug abuse, within the last 6 months prior
to the initiation of therapy

- Plans for administration of live vaccines during the study period or in the 12 weeks
prior to the initiation of therapy

- Bacillus Calmette-Guerin (BCG) vaccination within 12 months of starting the study or
with 12 months after completing the study