Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO



Status:Terminated
Conditions:Cardiology, Ocular, Ocular
Therapuetic Areas:Cardiology / Vascular Diseases, Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:January 31, 2017
End Date:December 10, 2018

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SAPPHIRE: A RANDOMIZED, MASKED, CONTROLLED TRIAL TO STUDY THE SAFETY AND EFFICACY OF SUPRACHOROIDAL CLS-TA IN CONJUNCTION WITH INTRAVITREAL AFLIBERCEPT IN SUBJECTS WITH RETINAL VEIN OCCLUSION

This is a Phase 3, multicenter, randomized, masked, controlled, parallel group study of 12
months duration in treatment naïve subjects with RVO.

A randomized, masked, controlled trial to study the safety and efficacy of suprachoroidal
CLS-TA in conjunction with intravitreal aflibercept in subjects with retinal veinocclusion

Inclusion Criteria:

- Has a clinical diagnosis of RVO in the study eye

- Has a CST of ≥ 300 µm in the study eye

- Has an ETDRS BCVA score of ≥ 20 letters read and ≤ 70 letters read in the study eye;

- Is naïve to local pharmacologic treatment for RVO in the study eye;

Exclusion Criteria:

- Any active ocular disease or infection in the study eye other than RVO

- History of glaucoma, intraocular pressure > 21 mmHg or ocular hypertension requiring
more than one medication

- Any uncontrolled systemic disease that, in the opinion of the Investigator, would
preclude participation in the study

- Any evidence of neovascularization in the study eye
We found this trial at
59
sites
628 Cedar Lane
Teaneck, New Jersey 07666
1286
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Teaneck, NJ
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
3719
mi
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'Aiea, HI
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388
mi
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Abilene, TX
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Arlington, Texas 76012
348
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Arlington, TX
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Asheville, North Carolina 28803
860
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Asheville, NC
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Atlanta, Georgia 30322
803
mi
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Atlanta, GA
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Augusta, Georgia 30909
936
mi
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Augusta, GA
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Austin, Texas 78705
515
mi
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Austin, TX
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5555 Business Park South
Bakersfield, California 93309
1187
mi
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Bakersfield, CA
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1148
mi
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Baltimore, MD
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9001 Wilshire Boulevard
Beverly Hills, California 90211
1176
mi
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Beverly Hills, CA
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1855 West Taylor Street
Chicago, Illinois 60612
608
mi
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Chicago, IL
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2845 North Sheridan Road
Chicago, Illinois 60657
612
mi
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Chicago, IL
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Cincinnati, Ohio 45242
726
mi
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Cincinnati, OH
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898
mi
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Cleveland, OH
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Dallas, Texas 75231
342
mi
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Dallas, TX
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Golden, Colorado 80401
422
mi
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Golden, CO
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Hagerstown, Maryland 21740
1089
mi
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Hagerstown, MD
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Hamden, Connecticut 06518
1345
mi
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Hamden, CT
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Houston, Texas 77030
572
mi
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Houston, TX
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7677 Center Avenue
Huntington Beach, California 92647
1162
mi
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Huntington Beach, CA
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Indianapolis, Indiana 46290
643
mi
from
Indianapolis, IN
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Kingston, Pennsylvania 18704
1190
mi
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Kingston, PA
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9415 Campus Point Drive
La Jolla, California 92093
1141
mi
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La Jolla, CA
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120 North Eagle Creek Drive
Lexington, Kentucky 40509
729
mi
from
Lexington, KY
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Madison, Wisconsin 53706
(608) 263-2400
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
574
mi
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Madison, WI
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Marietta, Georgia 30060
788
mi
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Marietta, GA
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McAllen, Texas 78503
797
mi
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McAllen, TX
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1518 East Barnett Road
Medford, Oregon 97504
1355
mi
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Medford, OR
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Miami, Florida 33143
1321
mi
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Miami, FL
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Mountain View, California 94040
1325
mi
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Mountain View, CA
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Oakland, California 94609
1330
mi
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Oakland, CA
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Palm Desert, California 92260
1074
mi
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Palm Desert, CA
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Palm Desert, California 92211
1071
mi
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Palm Desert, CA
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Pensacola, Florida 32503
789
mi
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Pensacola, FL
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15353 North 91st Avenue
Peoria, Arizona 85381
857
mi
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Peoria, AZ
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Philadelphia, Pennsylvania 19107
1225
mi
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Philadelphia, PA
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1101 East Missouri Avenue
Phoenix, Arizona 85014
850
mi
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Phoenix, AZ
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Phoenix, Arizona 85020
853
mi
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Phoenix, AZ
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852
mi
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Phoenix, AZ
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1384
mi
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Portland, OR
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Poway, California 92064
1129
mi
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Poway, CA
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Rapid City, South Dakota 57701
520
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Rapid City, SD
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Richmond, Virginia
1106
mi
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Richmond, VA
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Saint Louis, Missouri 63110
418
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Saint Louis, MO
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4344 Central Avenue North
Saint Petersburg, Florida 33711
1114
mi
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Saint Petersburg, FL
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Salt Lake City, UT
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San Antonio, Texas 78240
576
mi
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San Antonio, TX
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Santa Ana, California 92705
1155
mi
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Santa Ana, CA
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525 East Micheltorena Street
Santa Barbara, California 93103
1239
mi
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Santa Barbara, CA
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Sarasota, Florida 34239
1143
mi
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Sarasota, FL
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Shawnee Mission, Kansas 66204
190
mi
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Shawnee Mission, KS
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9-13 Redmyre Road
Strathfield, New South Wales 2135
8654
mi
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Strathfield,
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The Woodlands, Texas 77384
535
mi
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The Woodlands, TX
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Tucson, Arizona 85704
835
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Tucson, AZ
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Urbana, Illinois 61801
541
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Urbana, IL
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Walnut Creek, California 94598
1319
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Walnut Creek, CA
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Warrenton, Virginia 20186
1086
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Warrenton, VA
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Winter Haven, Florida 33880
1148
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Winter Haven, FL
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