COX-2 Inhibitor Study In Patients With Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:10/14/2017
Start Date:June 2005
End Date:September 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase III, 12-Week, Multicentre, Double-Blind, Randomised, Placebo- and Active Comparator-Controlled, Parallel Group Study to Investigate the Efficacy and Safety of GW406381, 5mg, 10mg, 25mg, and 50mg Administered Orally Once Daily, in Adults With Rheumatoid Arthritis

This study is being conducted to find out if an investigational drug called GW406381 can help
people with rheumatoid arthritis.


Inclusion criteria:

- Rheumatoid arthritis (RA) for at least 12 months.

- Required a non-steroidal anti-inflammatory drug (NSAID) or COX-2 inhibitor for RA for
at least 5 out of 7 days of each week for the 4 weeks prior to screening.

Exclusion criteria:

- Any history of cardiovascular disease (e.g., heart attack, stroke, congestive heart
failure, uncontrolled high blood pressure), documented peripheral arterial
insufficiency and symptomatic, clinically significant claudication, or who have a
history of peripheral arterial embolism.

- Have an active stomach ulcer or history of any stomach tear or bleeding.
We found this trial at
89
sites
GSK Investigational Site
Montgomery, Alabama 36109
2153
mi
from 98109
Montgomery, AL
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Anaheim, California 92807
981
mi
from 98109
Anaheim, CA
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GSK Investigational Site
Anniston, Alabama 36207
2117
mi
from 98109
Anniston, AL
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GSK Investigational Site
Atlanta, Georgia 30341
2176
mi
from 98109
Atlanta, GA
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GSK Investigational Site
Austin, Texas 78705
1769
mi
from 98109
Austin, TX
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GSK Investigational Site
Aventura, Florida 33180
2725
mi
from 98109
Aventura, FL
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GSK Investigational Site
Berlin, New Jersey 08009
2389
mi
from 98109
Berlin, NJ
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GSK Investigational Site
Birmingham, Alabama 35249
2072
mi
from 98109
Birmingham, AL
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GSK Investigational Site
Bridgeport, Connecticut 06606
2422
mi
from 98109
Bridgeport, CT
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GSK Investigational Site
Charleston, South Carolina 29425
2422
mi
from 98109
Charleston, SC
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GSK Investigational Site
Charlotte, North Carolina 28203
2281
mi
from 98109
Charlotte, NC
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GSK Investigational Site
Cleveland, Ohio 44195
2024
mi
from 98109
Cleveland, OH
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GSK Investigational Site
Colorado Springs, Colorado 80910
1070
mi
from 98109
Colorado Springs, CO
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GSK Investigational Site
Columbus, Ohio 43219
2009
mi
from 98109
Columbus, OH
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GSK Investigational Site
Concinnati, Ohio 45219
?
mi
from 98109
Concinnati, OH
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GSK Investigational Site
Cordoba, Córdova
?
mi
from 98109
Cordoba,
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GSK Investigational Site
Dallas, Texas 75230
1675
mi
from 98109
Dallas, TX
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GSK Investigational Site
Danbury, Connecticut 06810
2406
mi
from 98109
Danbury, CT
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GSK Investigational Site
Daytona Beach, Florida 32117
2528
mi
from 98109
Daytona Beach, FL
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GSK Investigational Site
DeLand, Florida 32720
2527
mi
from 98109
DeLand, FL
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GSK Investigational Site
Dover, New Hampshire 03820
2468
mi
from 98109
Dover, NH
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GSK Investigational Site
Duncansville, Pennsylvania 16635
2206
mi
from 98109
Duncansville, PA
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GSK Investigational Site
Dunedin, Florida 34698
2509
mi
from 98109
Dunedin, FL
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GSK Investigational Site
Evanston, Illinois 60201
1725
mi
from 98109
Evanston, IL
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GSK Investigational Site
Evansville, Indiana 47714
1868
mi
from 98109
Evansville, IN
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GSK Investigational Site
Everett, Washington 98201
26
mi
from 98109
Everett, WA
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GSK Investigational Site
Fall River, Massachusetts 02720
2502
mi
from 98109
Fall River, MA
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GSK Investigational Site
Gainsville, Georgia 30501
?
mi
from 98109
Gainsville, GA
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GSK Investigational Site
Gastonia, North Carolina 28054
2266
mi
from 98109
Gastonia, NC
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GSK Investigational Site
Glendale, Arizona 85304
1104
mi
from 98109
Glendale, AZ
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GSK Investigational Site
Greer, South Carolina 29651
2229
mi
from 98109
Greer, SC
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GSK Investigational Site
Hamden, Connecticut 06518
2429
mi
from 98109
Hamden, CT
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GSK Investigational Site
Hampton, South Carolina 29924
2364
mi
from 98109
Hampton, SC
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GSK Investigational Site
Hickory, North Carolina 28601
2238
mi
from 98109
Hickory, NC
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GSK Investigational Site
Huntsville, Alabama 35801
2039
mi
from 98109
Huntsville, AL
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GSK Investigational Site
Idaho Falls, Idaho 83404
575
mi
from 98109
Idaho Falls, ID
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GSK Investigational Site
Indianapolis, Indiana 46202
1867
mi
from 98109
Indianapolis, IN
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GSK Investigational Site
Johnson City, New York 13790
2267
mi
from 98109
Johnson City, NY
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GSK Investigational Site
Kalamazoo, Michigan 49007
1816
mi
from 98109
Kalamazoo, MI
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GSK Investigational Site
Kingston, New York 12401
2364
mi
from 98109
Kingston, NY
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GSK Investigational Site
Lansing, Michigan 48917
1848
mi
from 98109
Lansing, MI
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GSK Investigational Site
Largo, Florida 33770
2513
mi
from 98109
Largo, FL
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GSK Investigational Site
Las Vegas, Nevada 89102
874
mi
from 98109
Las Vegas, NV
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GSK Investigational Site
Louisville, Kentucky 40202
1939
mi
from 98109
Louisville, KY
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GSK Investigational Site
Mayfield Village, Ohio 44143
?
mi
from 98109
Mayfield Village, OH
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GSK Investigational Site
Medford, Oregon 97504
367
mi
from 98109
Medford, OR
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GSK Investigational Site
Memphis, Tennessee 38120
1874
mi
from 98109
Memphis, TN
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GSK Investigational Site
Mercerville, New Jersey 08619
2386
mi
from 98109
Mercerville, NJ
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GSK Investigational Site
Miami, Florida 33136
2730
mi
from 98109
Miami, FL
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GSK Investigational Site
Morton Grove, Illinois 60053
1721
mi
from 98109
Morton Grove, IL
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GSK Investigational Site
Murrells Inlet, South Carolina 29576
2432
mi
from 98109
Murrells Inlet, SC
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GSK Investigational Site
New Orleans, Louisiana 70112
2099
mi
from 98109
New Orleans, LA
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GSK Investigational Site
New York, New York 10032
2400
mi
from 98109
New York, NY
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GSK Investigational Site
North Massapequa, New York 11758
2427
mi
from 98109
North Massapequa, NY
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GSK Investigational Site
Ocala, Florida 34471
2485
mi
from 98109
Ocala, FL
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GSK Investigational Site
Oklahoma City, Oklahoma 73112
1519
mi
from 98109
Oklahoma City, OK
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GSK Investigational Site
Orlando, Florida 32806
2549
mi
from 98109
Orlando, FL
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GSK Investigational Site
Palm Desert, California 92260
1011
mi
from 98109
Palm Desert, CA
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GSK Investigational Site
Palm Harbor, Florida 34684
2509
mi
from 98109
Palm Harbor, FL
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GSK Investigational Site
Philadelphia, Pennsylvania 19104
2371
mi
from 98109
Philadelphia, PA
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GSK Investigational Site
Port Orange, Florida 32129
2535
mi
from 98109
Port Orange, FL
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GSK Investigational Site
Prairie Village, Kansas 66208
1505
mi
from 98109
Prairie Village, KS
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GSK Investigational Site
Racine, Wisconsin 53404
1702
mi
from 98109
Racine, WI
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GSK Investigational Site
Reno, Nevada 89502
578
mi
from 98109
Reno, NV
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GSK Investigational Site
Rochester, New York 14642
2161
mi
from 98109
Rochester, NY
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GSK Investigational Site
Roswell, Georgia 30076
2170
mi
from 98109
Roswell, GA
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GSK Investigational Site
San Antonio, Texas 78258
1776
mi
from 98109
San Antonio, TX
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GSK Investigational Site
San Diego, California 92111
1058
mi
from 98109
San Diego, CA
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GSK Investigational Site
Santa Monica, California 90404
961
mi
from 98109
Santa Monica, CA
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GSK Investigational Site
Scottsdale, Arizona 85259
1114
mi
from 98109
Scottsdale, AZ
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GSK Investigational Site
Slidell, Louisiana 70458
2096
mi
from 98109
Slidell, LA
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GSK Investigational Site
Springfield, Illinois 62702
1705
mi
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Springfield, IL
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GSK Investigational Site
Springfield, Massachusetts 01199
2422
mi
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Springfield, MA
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GSK Investigational Site
St. Louis, Missouri 63110
1718
mi
from 98109
St. Louis, MO
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GSK Investigational Site
Statesville, North Carolina 28625
2257
mi
from 98109
Statesville, NC
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GSK Investigational Site
Stuart, Florida 34994
2660
mi
from 98109
Stuart, FL
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GSK Investigational Site
Tampa, Florida 33612
2522
mi
from 98109
Tampa, FL
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GSK Investigational Site
Trinity, Florida 34655
2506
mi
from 98109
Trinity, FL
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GSK Investigational Site
Trumbull, Connecticut 06611
2422
mi
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Trumbull, CT
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GSK Investigational Site
Tucson, Arizona 85724
1219
mi
from 98109
Tucson, AZ
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GSK Investigational Site
Tulsa, Oklahoma 74105
1561
mi
from 98109
Tulsa, OK
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GSK Investigational Site
Upland, California 91786
965
mi
from 98109
Upland, CA
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GSK Investigational Site
Vancouver, Washington 98684
139
mi
from 98109
Vancouver, WA
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GSK Investigational Site
West Palm Beach, Florida 33409
2690
mi
from 98109
West Palm Beach, FL
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GSK Investigational Site
West Reading, Pennsylvania 19611
2324
mi
from 98109
West Reading, PA
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GSK Investigational Site
Wheaton, Maryland 20902
2316
mi
from 98109
Wheaton, MD
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GSK Investigational Site
Wichita, Kansas 67207
1440
mi
from 98109
Wichita, KS
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GSK Investigational Site
Woodstock, Georgia 30189
2158
mi
from 98109
Woodstock, GA
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GSK Investigational Site
Zephyrhills, Florida 33540
2525
mi
from 98109
Zephyrhills, FL
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