COX-2 Inhibitor Study In Patients With Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:10/14/2017
Start Date:June 2005
End Date:September 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase III, 12-Week, Multicentre, Double-Blind, Randomised, Placebo- and Active Comparator-Controlled, Parallel Group Study to Investigate the Efficacy and Safety of GW406381, 5mg, 10mg, 25mg, and 50mg Administered Orally Once Daily, in Adults With Rheumatoid Arthritis

This study is being conducted to find out if an investigational drug called GW406381 can help
people with rheumatoid arthritis.


Inclusion criteria:

- Rheumatoid arthritis (RA) for at least 12 months.

- Required a non-steroidal anti-inflammatory drug (NSAID) or COX-2 inhibitor for RA for
at least 5 out of 7 days of each week for the 4 weeks prior to screening.

Exclusion criteria:

- Any history of cardiovascular disease (e.g., heart attack, stroke, congestive heart
failure, uncontrolled high blood pressure), documented peripheral arterial
insufficiency and symptomatic, clinically significant claudication, or who have a
history of peripheral arterial embolism.

- Have an active stomach ulcer or history of any stomach tear or bleeding.
We found this trial at
89
sites
GSK Investigational Site
Indianapolis, Indiana 46202
166
mi
from 43215
Indianapolis, IN
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GSK Investigational Site
Anaheim, California 92807
1953
mi
from 43215
Anaheim, CA
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GSK Investigational Site
Anniston, Alabama 36207
462
mi
from 43215
Anniston, AL
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GSK Investigational Site
Atlanta, Georgia 30341
424
mi
from 43215
Atlanta, GA
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GSK Investigational Site
Austin, Texas 78705
1064
mi
from 43215
Austin, TX
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GSK Investigational Site
Aventura, Florida 33180
982
mi
from 43215
Aventura, FL
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GSK Investigational Site
Berlin, New Jersey 08009
429
mi
from 43215
Berlin, NJ
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GSK Investigational Site
Birmingham, Alabama 35249
493
mi
from 43215
Birmingham, AL
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GSK Investigational Site
Bridgeport, Connecticut 06606
521
mi
from 43215
Bridgeport, CT
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GSK Investigational Site
Charleston, South Carolina 29425
524
mi
from 43215
Charleston, SC
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GSK Investigational Site
Charlotte, North Carolina 28203
348
mi
from 43215
Charlotte, NC
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GSK Investigational Site
Cleveland, Ohio 44195
129
mi
from 43215
Cleveland, OH
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GSK Investigational Site
Colorado Springs, Colorado 80910
1161
mi
from 43215
Colorado Springs, CO
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GSK Investigational Site
Columbus, Ohio 43219
7
mi
from 43215
Columbus, OH
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GSK Investigational Site
Concinnati, Ohio 45219
?
mi
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Concinnati, OH
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GSK Investigational Site
Cordoba, Córdova
?
mi
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Cordoba,
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GSK Investigational Site
Dallas, Texas 75230
905
mi
from 43215
Dallas, TX
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GSK Investigational Site
Danbury, Connecticut 06810
510
mi
from 43215
Danbury, CT
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GSK Investigational Site
Daytona Beach, Florida 32117
749
mi
from 43215
Daytona Beach, FL
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GSK Investigational Site
DeLand, Florida 32720
761
mi
from 43215
DeLand, FL
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GSK Investigational Site
Dover, New Hampshire 03820
665
mi
from 43215
Dover, NH
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GSK Investigational Site
Duncansville, Pennsylvania 16635
244
mi
from 43215
Duncansville, PA
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GSK Investigational Site
Dunedin, Florida 34698
825
mi
from 43215
Dunedin, FL
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GSK Investigational Site
Evanston, Illinois 60201
283
mi
from 43215
Evanston, IL
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GSK Investigational Site
Evansville, Indiana 47714
278
mi
from 43215
Evansville, IN
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GSK Investigational Site
Everett, Washington 98201
2000
mi
from 43215
Everett, WA
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GSK Investigational Site
Fall River, Massachusetts 02720
633
mi
from 43215
Fall River, MA
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GSK Investigational Site
Gainsville, Georgia 30501
?
mi
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Gainsville, GA
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GSK Investigational Site
Gastonia, North Carolina 28054
341
mi
from 43215
Gastonia, NC
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GSK Investigational Site
Glendale, Arizona 85304
1663
mi
from 43215
Glendale, AZ
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GSK Investigational Site
Greer, South Carolina 29651
350
mi
from 43215
Greer, SC
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GSK Investigational Site
Hamden, Connecticut 06518
538
mi
from 43215
Hamden, CT
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GSK Investigational Site
Hampton, South Carolina 29924
500
mi
from 43215
Hampton, SC
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GSK Investigational Site
Hickory, North Carolina 28601
306
mi
from 43215
Hickory, NC
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GSK Investigational Site
Huntsville, Alabama 35801
409
mi
from 43215
Huntsville, AL
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GSK Investigational Site
Idaho Falls, Idaho 83404
1507
mi
from 43215
Idaho Falls, ID
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GSK Investigational Site
Johnson City, New York 13790
396
mi
from 43215
Johnson City, NY
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GSK Investigational Site
Kalamazoo, Michigan 49007
209
mi
from 43215
Kalamazoo, MI
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GSK Investigational Site
Kingston, New York 12401
489
mi
from 43215
Kingston, NY
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GSK Investigational Site
Lansing, Michigan 48917
208
mi
from 43215
Lansing, MI
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GSK Investigational Site
Largo, Florida 33770
832
mi
from 43215
Largo, FL
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GSK Investigational Site
Las Vegas, Nevada 89102
1759
mi
from 43215
Las Vegas, NV
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GSK Investigational Site
Louisville, Kentucky 40202
188
mi
from 43215
Louisville, KY
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GSK Investigational Site
Mayfield Village, Ohio 44143
?
mi
from 43215
Mayfield Village, OH
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GSK Investigational Site
Medford, Oregon 97504
2060
mi
from 43215
Medford, OR
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GSK Investigational Site
Memphis, Tennessee 38120
501
mi
from 43215
Memphis, TN
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GSK Investigational Site
Mercerville, New Jersey 08619
440
mi
from 43215
Mercerville, NJ
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GSK Investigational Site
Miami, Florida 33136
992
mi
from 43215
Miami, FL
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GSK Investigational Site
Montgomery, Alabama 36109
553
mi
from 43215
Montgomery, AL
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GSK Investigational Site
Morton Grove, Illinois 60053
286
mi
from 43215
Morton Grove, IL
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GSK Investigational Site
Murrells Inlet, South Carolina 29576
494
mi
from 43215
Murrells Inlet, SC
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GSK Investigational Site
New Orleans, Louisiana 70112
797
mi
from 43215
New Orleans, LA
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GSK Investigational Site
New York, New York 10032
481
mi
from 43215
New York, NY
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GSK Investigational Site
North Massapequa, New York 11758
505
mi
from 43215
North Massapequa, NY
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GSK Investigational Site
Ocala, Florida 34471
748
mi
from 43215
Ocala, FL
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GSK Investigational Site
Oklahoma City, Oklahoma 73112
851
mi
from 43215
Oklahoma City, OK
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GSK Investigational Site
Orlando, Florida 32806
797
mi
from 43215
Orlando, FL
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GSK Investigational Site
Palm Desert, California 92260
1884
mi
from 43215
Palm Desert, CA
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GSK Investigational Site
Palm Harbor, Florida 34684
821
mi
from 43215
Palm Harbor, FL
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GSK Investigational Site
Philadelphia, Pennsylvania 19104
414
mi
from 43215
Philadelphia, PA
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GSK Investigational Site
Port Orange, Florida 32129
756
mi
from 43215
Port Orange, FL
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GSK Investigational Site
Prairie Village, Kansas 66208
622
mi
from 43215
Prairie Village, KS
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GSK Investigational Site
Racine, Wisconsin 53404
311
mi
from 43215
Racine, WI
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GSK Investigational Site
Reno, Nevada 89502
1936
mi
from 43215
Reno, NV
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GSK Investigational Site
Rochester, New York 14642
354
mi
from 43215
Rochester, NY
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GSK Investigational Site
Roswell, Georgia 30076
416
mi
from 43215
Roswell, GA
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GSK Investigational Site
San Antonio, Texas 78258
1126
mi
from 43215
San Antonio, TX
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GSK Investigational Site
San Diego, California 92111
1948
mi
from 43215
San Diego, CA
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GSK Investigational Site
Santa Monica, California 90404
1984
mi
from 43215
Santa Monica, CA
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GSK Investigational Site
Scottsdale, Arizona 85259
1644
mi
from 43215
Scottsdale, AZ
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GSK Investigational Site
Slidell, Louisiana 70458
770
mi
from 43215
Slidell, LA
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GSK Investigational Site
Springfield, Illinois 62702
349
mi
from 43215
Springfield, IL
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GSK Investigational Site
Springfield, Massachusetts 01199
562
mi
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Springfield, MA
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GSK Investigational Site
St. Louis, Missouri 63110
397
mi
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St. Louis, MO
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GSK Investigational Site
Statesville, North Carolina 28625
311
mi
from 43215
Statesville, NC
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GSK Investigational Site
Stuart, Florida 34994
896
mi
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Stuart, FL
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GSK Investigational Site
Tampa, Florida 33612
823
mi
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Tampa, FL
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GSK Investigational Site
Trinity, Florida 34655
814
mi
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Trinity, FL
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GSK Investigational Site
Trumbull, Connecticut 06611
522
mi
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Trumbull, CT
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GSK Investigational Site
Tucson, Arizona 85724
1639
mi
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Tucson, AZ
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GSK Investigational Site
Tulsa, Oklahoma 74105
752
mi
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Tulsa, OK
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GSK Investigational Site
Upland, California 91786
1940
mi
from 43215
Upland, CA
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GSK Investigational Site
Vancouver, Washington 98684
2018
mi
from 43215
Vancouver, WA
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GSK Investigational Site
West Palm Beach, Florida 33409
930
mi
from 43215
West Palm Beach, FL
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GSK Investigational Site
West Reading, Pennsylvania 19611
374
mi
from 43215
West Reading, PA
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GSK Investigational Site
Wheaton, Maryland 20902
324
mi
from 43215
Wheaton, MD
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GSK Investigational Site
Wichita, Kansas 67207
780
mi
from 43215
Wichita, KS
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GSK Investigational Site
Woodstock, Georgia 30189
413
mi
from 43215
Woodstock, GA
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GSK Investigational Site
Zephyrhills, Florida 33540
811
mi
from 43215
Zephyrhills, FL
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