Effect of Inhaled Pre-prandial Human Insulin on Blood Glucose Control in Type 2 Diabetes



Status:Terminated
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:9/7/2018
Start Date:January 10, 2007
End Date:March 11, 2008

Use our guide to learn which trials are right for you!

Effect of Inhaled Pre-Prandial Human Insulin Plus Metformin & Glimepiride Versus Rosiglitazone Plus Metformin & Glimepiride on HbA1c in Subjects With Type 2 Diabetes

This trial is conducted in the United States of America (USA). This trial will compare the
changes in HbA1c after 26 weeks of inhaled insulin or rosiglitazone treatment, both in
combination with metformin and glimepiride.

The decision to discontinue the development of AERx® is not due to any safety concerns. An
analysis concluded that fast-acting inhaled insulin in the form it is known today, is
unlikely to offer significant clinical or convenience benefits over injections of modern
insulin with pen devices.

Inclusion Criteria:

- Type 2 diabetes

- Currently treated with antidiabetes drugs (including Exenatide) for at least 2 months

- HbA1c between 7.5 and 11.0% (both inclusive) on antidiabetes combination therapy

- BMI less than or equal to 40 kg/m2

Exclusion Criteria:

- Current smoking or smoking within the last 6 months

- Current acute or chronic pulmonary disease (except for asthma)

- Proliferative retinopathy requiring acute treatment

- Clinically significant disease history including kidney or liver disease

- Heart disease which limits physical activity or results in discomfort with physical
activity

- Pregnancy
We found this trial at
98
sites
San Diego, California 92111
106
mi
from 91732
San Diego, CA
Click here to add this to my saved trials
Altoona, Pennsylvania 16602
2203
mi
from 91732
Altoona, PA
Click here to add this to my saved trials
Arlington, Texas 76012
1205
mi
from 91732
Arlington, TX
Click here to add this to my saved trials
Arlington, Virginia 22206
2277
mi
from 91732
Arlington, VA
Click here to add this to my saved trials
Asheville, North Carolina 28801
2002
mi
from 91732
Asheville, NC
Click here to add this to my saved trials
Athens, Georgia 30606
1973
mi
from 91732
Athens, GA
Click here to add this to my saved trials
Atlanta, Georgia 30318
1919
mi
from 91732
Atlanta, GA
Click here to add this to my saved trials
Augusta, Georgia 30912
2059
mi
from 91732
Augusta, GA
Click here to add this to my saved trials
Baltimore, Maryland 21229
2297
mi
from 91732
Baltimore, MD
Click here to add this to my saved trials
Beaver, Pennsylvania 15009
2103
mi
from 91732
Beaver, PA
Click here to add this to my saved trials
Berlin, New Jersey 08009
2388
mi
from 91732
Berlin, NJ
Click here to add this to my saved trials
Billings, Montana 59101
951
mi
from 91732
Billings, MT
Click here to add this to my saved trials
Boca Raton, Florida 33433
2312
mi
from 91732
Boca Raton, FL
Click here to add this to my saved trials
667
mi
from 91732
Boise, ID
Click here to add this to my saved trials
Charlotte, North Carolina 28277
2101
mi
from 91732
Charlotte, NC
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
1855
mi
from 91732
Chattanooga, TN
Click here to add this to my saved trials
Cherry Hill, New Jersey 08034
2382
mi
from 91732
Cherry Hill, NJ
Click here to add this to my saved trials
Chesterfield, Missouri 63017
1552
mi
from 91732
Chesterfield, MO
Click here to add this to my saved trials
Chicago, Illinois 60612
1728
mi
from 91732
Chicago, IL
Click here to add this to my saved trials
Cincinnati, Ohio 45229
1881
mi
from 91732
Cincinnati, OH
Click here to add this to my saved trials
Clarksville, Tennessee 37043
1729
mi
from 91732
Clarksville, TN
Click here to add this to my saved trials
Clearwater, Florida 33756
2117
mi
from 91732
Clearwater, FL
Click here to add this to my saved trials
Cleveland, Ohio 44106
2032
mi
from 91732
Cleveland, OH
Click here to add this to my saved trials
Clinton, Oklahoma 73601
1083
mi
from 91732
Clinton, OK
Click here to add this to my saved trials
Colorado Springs, Colorado 80910
804
mi
from 91732
Colorado Springs, CO
Click here to add this to my saved trials
Concord, California 94520
353
mi
from 91732
Concord, CA
Click here to add this to my saved trials
Dallas, Texas 75231
1225
mi
from 91732
Dallas, TX
Click here to add this to my saved trials
1894
mi
from 91732
Dayton, OH
Click here to add this to my saved trials
Des Moines, Iowa 50314
1422
mi
from 91732
Des Moines, IA
Click here to add this to my saved trials
Dunwoody, Georgia 30338
1920
mi
from 91732
Dunwoody, GA
Click here to add this to my saved trials
Escondido, California 92025
84
mi
from 91732
Escondido, CA
Click here to add this to my saved trials
Fresno, California 93702
209
mi
from 91732
Fresno, CA
Click here to add this to my saved trials
Greenville, North Carolina 27834
2290
mi
from 91732
Greenville, NC
Click here to add this to my saved trials
Greer, South Carolina 29651
2027
mi
from 91732
Greer, SC
Click here to add this to my saved trials
Hialeah, Florida 33012
2314
mi
from 91732
Hialeah, FL
Click here to add this to my saved trials
High Point, North Carolina 27265
1997
mi
from 91732
High Point, NC
Click here to add this to my saved trials
Hollywood, Florida 33024
2318
mi
from 91732
Hollywood, FL
Click here to add this to my saved trials
Honolulu, Hawaii 96814
2572
mi
from 91732
Honolulu, HI
Click here to add this to my saved trials
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
Click here to add this to my saved trials
Hueytown, Alabama 35023
1775
mi
from 91732
Hueytown, AL
Click here to add this to my saved trials
Huntington Beach, California 92648
28
mi
from 91732
Huntington Beach, CA
Click here to add this to my saved trials
1201
mi
from 91732
Hurst, TX
Click here to add this to my saved trials
Jackson, Mississippi 39209
1608
mi
from 91732
Jackson, MS
Click here to add this to my saved trials
Jefferson City, Missouri 65109
1466
mi
from 91732
Jefferson City, MO
Click here to add this to my saved trials
Kansas City, Missouri 64106
1341
mi
from 91732
Kansas City, MO
Click here to add this to my saved trials
Kingsport, Tennessee 37660
1994
mi
from 91732
Kingsport, TN
Click here to add this to my saved trials
La Jolla, California 92037
95
mi
from 91732
La Jolla, CA
Click here to add this to my saved trials
Lafayette, Indiana 47904
1757
mi
from 91732
Lafayette, IN
Click here to add this to my saved trials
Lake Mary, Florida 32746
2182
mi
from 91732
Lake Mary, FL
Click here to add this to my saved trials
Las Vegas, Nevada 89128
213
mi
from 91732
Las Vegas, NV
Click here to add this to my saved trials
Lawrenceville, New Jersey 08648
2396
mi
from 91732
Lawrenceville, NJ
Click here to add this to my saved trials
Lewisville, Texas 75067
1210
mi
from 91732
Lewisville, TX
Click here to add this to my saved trials
Lexington, Kentucky 40503
1879
mi
from 91732
Lexington, KY
Click here to add this to my saved trials
Marianna, Florida 32446
1917
mi
from 91732
Marianna, FL
Click here to add this to my saved trials
Marlborough, Massachusetts 01752
2553
mi
from 91732
Marlborough, MA
Click here to add this to my saved trials
Medford, Oregon 97501
628
mi
from 91732
Medford, OR
Click here to add this to my saved trials
Melbourne, Florida 32901
2239
mi
from 91732
Melbourne, FL
Click here to add this to my saved trials
Merritt Island, Florida 32953
2224
mi
from 91732
Merritt Island, FL
Click here to add this to my saved trials
Miami, Florida 33136
2321
mi
from 91732
Miami, FL
Click here to add this to my saved trials
Norfolk, Virginia 23510
2337
mi
from 91732
Norfolk, VA
Click here to add this to my saved trials
Norristown, Pennsylvania 19401
2365
mi
from 91732
Norristown, PA
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
1165
mi
from 91732
Oklahoma City, OK
Click here to add this to my saved trials
Omaha, Nebraska 68114
1301
mi
from 91732
Omaha, NE
Click here to add this to my saved trials
Orange, California 92868
21
mi
from 91732
Orange, CA
Click here to add this to my saved trials
Ozark, Alabama 36360
1881
mi
from 91732
Ozark, AL
Click here to add this to my saved trials
Palm Harbor, Florida 34684
2115
mi
from 91732
Palm Harbor, FL
Click here to add this to my saved trials
Pembroke Pines, Florida 33026
2314
mi
from 91732
Pembroke Pines, FL
Click here to add this to my saved trials
Peoria, Illinois 61615
1618
mi
from 91732
Peoria, IL
Click here to add this to my saved trials
Poway, California 92064
95
mi
from 91732
Poway, CA
Click here to add this to my saved trials
Powder Springs, Georgia 30127
1901
mi
from 91732
Powder Springs, GA
Click here to add this to my saved trials
Renton, Washington 98057
952
mi
from 91732
Renton, WA
Click here to add this to my saved trials
Richmond, Virginia 23219
2267
mi
from 91732
Richmond, VA
Click here to add this to my saved trials
Roseville, California 95661
369
mi
from 91732
Roseville, CA
Click here to add this to my saved trials
Roswell, Georgia 30076
1918
mi
from 91732
Roswell, GA
Click here to add this to my saved trials
Sacramento, California 95821
366
mi
from 91732
Sacramento, CA
Click here to add this to my saved trials
Saint Louis, Missouri 63110
1573
mi
from 91732
Saint Louis, MO
Click here to add this to my saved trials
San Antonio, Texas 78224
1188
mi
from 91732
San Antonio, TX
Click here to add this to my saved trials
Santa Barbara, California 93105
99
mi
from 91732
Santa Barbara, CA
Click here to add this to my saved trials
Scarborough, Maine 04074
2611
mi
from 91732
Scarborough, ME
Click here to add this to my saved trials
Shawnee Mission, Kansas 66204
?
mi
from 91732
Shawnee Mission, KS
Click here to add this to my saved trials
Springfield, Illinois 62702
1610
mi
from 91732
Springfield, IL
Click here to add this to my saved trials
Springfield, Massachusetts 01107
2501
mi
from 91732
Springfield, MA
Click here to add this to my saved trials
Staten Island, New York 10301
2426
mi
from 91732
Staten Island, NY
Click here to add this to my saved trials
Suwanee, Georgia 30024
1933
mi
from 91732
Suwanee, GA
Click here to add this to my saved trials
Syracuse, New York 13210
2319
mi
from 91732
Syracuse, NY
Click here to add this to my saved trials
Tacoma, Washington 98405
939
mi
from 91732
Tacoma, WA
Click here to add this to my saved trials
Temecula, California 92591
64
mi
from 91732
Temecula, CA
Click here to add this to my saved trials
Topeka, Kansas 66606
1282
mi
from 91732
Topeka, KS
Click here to add this to my saved trials
Tucker, Georgia 30084
1927
mi
from 91732
Tucker, GA
Click here to add this to my saved trials
Tucson, Arizona 85704
423
mi
from 91732
Tucson, AZ
Click here to add this to my saved trials
Tuscaloosa, Alabama 35406
1745
mi
from 91732
Tuscaloosa, AL
Click here to add this to my saved trials
Vero Beach, Florida 32960
2261
mi
from 91732
Vero Beach, FL
Click here to add this to my saved trials
Vestavia Hills, Alabama 35209
1787
mi
from 91732
Vestavia Hills, AL
Click here to add this to my saved trials
Walnut Creek, California 94598
354
mi
from 91732
Walnut Creek, CA
Click here to add this to my saved trials
Warrenton, Virginia 20186
2241
mi
from 91732
Warrenton, VA
Click here to add this to my saved trials
Waterbury, Connecticut 06708
2477
mi
from 91732
Waterbury, CT
Click here to add this to my saved trials
West Palm Beach, Florida 33409
2304
mi
from 91732
West Palm Beach, FL
Click here to add this to my saved trials
Wichita, Kansas 67205
1181
mi
from 91732
Wichita, KS
Click here to add this to my saved trials