Effect of Inhaled Insulin (AERx® iDMS) on Blood Glucose Control in Type 2 Diabetes



Status:Terminated
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:9/7/2018
Start Date:November 29, 2006
End Date:March 18, 2008

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Trial Summary
Trial Overview
Inclusion Criteria

Effect of Inhaled Insulin (AERx® iDMS) Plus Pioglitazone Versus Pioglitazone Alone on HbA1c in Subjects With Type 2 Diabetes

This trial is conducted in the United States of America (USA). This trial will compare the
changes in HbA1c after 26 weeks of inhaled insulin and pioglitazone combination therapy
versus pioglitazone treatment alone.

The decision to discontinue the development of AERx® is not due to any safety concerns. An
analysis concluded that fast-acting inhaled insulin in the form it is known today, is
unlikely to offer significant clinical or convenience benefits over injections of modern
insulin with pen devices.

Inclusion Criteria:

- Type 2 diabetes

- Current treatment with oral antidiabetes drugs (OADs) for at least 2 months

- HbA1c between 7.0-11.0% if on OAD monotherapy

- HbA1c between 7.0-10.0% if on OAD combination therapy

- BMI less than or equal to 40 kg/m2

Exclusion Criteria:

- Current regular smoking or regular smoking within the last 6 months

- Current acute or chronic pulmonary disease (except for asthma)

- Proliferative retinopathy requiring treatment

- Clinically significant disease history including kidney or liver disease, or heart
disease which limits physical activity or results in discomfort with physical activity

- Pregnancy
We found this trial at
103
sites
Novo Nordisk Investigational Site
Waltham, Massachusetts 02453
2476
mi
from 98109
Waltham, MA
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Altoona, Pennsylvania 16602
2204
mi
from 98109
Altoona, PA
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Arlington, Texas 76012
1667
mi
from 98109
Arlington, TX
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Novo Nordisk Investigational Site
Arlington, Virginia 22206
2319
mi
from 98109
Arlington, VA
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Novo Nordisk Investigational Site
Arvada, Colorado 80005
1013
mi
from 98109
Arvada, CO
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Novo Nordisk Investigational Site
Athens, Georgia 30606
2216
mi
from 98109
Athens, GA
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Novo Nordisk Investigational Site
Atlanta, Georgia 30318
2179
mi
from 98109
Atlanta, GA
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Novo Nordisk Investigational Site
Avon, Illinois 46123
1640
mi
from 98109
Avon, IL
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Baltimore, Maryland 21229
2325
mi
from 98109
Baltimore, MD
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Novo Nordisk Investigational Site
Beaver, Pennsylvania 15009
2110
mi
from 98109
Beaver, PA
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Bensalem, Pennsylvania 19020
2378
mi
from 98109
Bensalem, PA
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Bermuda Dunes, California 92203
1009
mi
from 98109
Bermuda Dunes, CA
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Novo Nordisk Investigational Site
Beverly Hills, Florida 34465
2481
mi
from 98109
Beverly Hills, FL
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Novo Nordisk Investigational Site
Billings, Montana 59101
667
mi
from 98109
Billings, MT
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Novo Nordisk Investigational Site
Bismarck, North Dakota 58501
1009
mi
from 98109
Bismarck, ND
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Bloomington, Minnesota 55420
1392
mi
from 98109
Bloomington, MN
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Blue Ridge, Georgia 30513
2135
mi
from 98109
Blue Ridge, GA
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Boca Raton, Florida 33433
2708
mi
from 98109
Boca Raton, FL
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Boise, Idaho 83712
409
mi
from 98109
Boise, ID
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Canal Fulton, Ohio 44614
2044
mi
from 98109
Canal Fulton, OH
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Charlotte, North Carolina 28277
2281
mi
from 98109
Charlotte, NC
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Chesterfield, Missouri 63017
1702
mi
from 98109
Chesterfield, MO
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Chicago, Illinois 60612
1733
mi
from 98109
Chicago, IL
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Cincinnati, Ohio 45229
1966
mi
from 98109
Cincinnati, OH
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Clarksville, Tennessee 37043
1930
mi
from 98109
Clarksville, TN
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Novo Nordisk Investigational Site
Clearwater, Florida 33756
2512
mi
from 98109
Clearwater, FL
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Cleveland, Ohio 44106
2020
mi
from 98109
Cleveland, OH
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Clinton, Oklahoma 73601
1460
mi
from 98109
Clinton, OK
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Colorado Springs, Colorado 80910
1070
mi
from 98109
Colorado Springs, CO
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Dallas, Texas 75231
1677
mi
from 98109
Dallas, TX
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Novo Nordisk Investigational Site
Dayton, Ohio 45406
1956
mi
from 98109
Dayton, OH
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Des Moines, Iowa 50314
1462
mi
from 98109
Des Moines, IA
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Dunwoody, Georgia 30338
2173
mi
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Dunwoody, GA
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Escondido, California 92025
1039
mi
from 98109
Escondido, CA
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Fresno, California 93702
763
mi
from 98109
Fresno, CA
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Greer, South Carolina 29651
2229
mi
from 98109
Greer, SC
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Hershey, Pennsylvania 17033
2293
mi
from 98109
Hershey, PA
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Hialeah, Florida 33012
2724
mi
from 98109
Hialeah, FL
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High Point, North Carolina 27265
2183
mi
from 98109
High Point, NC
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Hollywood, Florida 33024
2722
mi
from 98109
Hollywood, FL
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Honolulu, Hawaii 96814
2679
mi
from 98109
Honolulu, HI
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Houston, Texas 77030
1892
mi
from 98109
Houston, TX
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Huntington Beach, California 92648
991
mi
from 98109
Huntington Beach, CA
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Jackson, Mississippi 39209
1983
mi
from 98109
Jackson, MS
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Jefferson City, Missouri 65109
1632
mi
from 98109
Jefferson City, MO
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Kansas City, Missouri 64106
1503
mi
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Kansas City, MO
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Kingsport, Tennessee 37660
2150
mi
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Kingsport, TN
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La Jolla, California 92037
1056
mi
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La Jolla, CA
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Lafayette, Indiana 47904
1813
mi
from 98109
Lafayette, IN
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Lake Mary, Florida 32746
2539
mi
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Lake Mary, FL
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Las Vegas, Nevada 89128
868
mi
from 98109
Las Vegas, NV
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Lewisville, Texas 75067
1659
mi
from 98109
Lewisville, TX
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Lexington, Kentucky 40503
2004
mi
from 98109
Lexington, KY
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Little Rock, Arkansas 72202
1782
mi
from 98109
Little Rock, AR
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Marianna, Florida 32446
2272
mi
from 98109
Marianna, FL
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Marlborough, Massachusetts 01752
2463
mi
from 98109
Marlborough, MA
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Medford, Oregon 97501
367
mi
from 98109
Medford, OR
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Melbourne, Florida 32901
2603
mi
from 98109
Melbourne, FL
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Miami, Florida 33136
2730
mi
from 98109
Miami, FL
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Novo Nordisk Investigational Site
Niceville, Florida 32578
2228
mi
from 98109
Niceville, FL
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Norfolk, Virginia 23510
2430
mi
from 98109
Norfolk, VA
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Norristown, Pennsylvania 19401
2359
mi
from 98109
Norristown, PA
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Northridge, California 91325
946
mi
from 98109
Northridge, CA
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Oklahoma City, Oklahoma 73112
1523
mi
from 98109
Oklahoma City, OK
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Orange, California 92868
984
mi
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Orange, CA
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Ozark, Alabama 36360
2222
mi
from 98109
Ozark, AL
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Palm Harbor, Florida 34684
2507
mi
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Palm Harbor, FL
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Panama City, Florida 32401
2281
mi
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Panama City, FL
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Pembroke Pines, Florida 33026
2719
mi
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Pembroke Pines, FL
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Peoria, Illinois 61615
1678
mi
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Peoria, IL
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Plano, Texas 75075
1671
mi
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Plano, TX
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Poway, California 92064
1050
mi
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Poway, CA
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Powder Springs, Georgia 30127
2160
mi
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Powder Springs, GA
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Prince Frederick, Maryland 20678
2355
mi
from 98109
Prince Frederick, MD
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Raleigh, North Carolina 27610
2362
mi
from 98109
Raleigh, NC
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Richmond, Virginia 23219
2350
mi
from 98109
Richmond, VA
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Roseville, California 95661
616
mi
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Roseville, CA
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Roswell, Georgia 30076
2168
mi
from 98109
Roswell, GA
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Sacramento, California 95821
626
mi
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Sacramento, CA
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Saint George, Utah 84790
852
mi
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Saint George, UT
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Saint Louis, Missouri 63110
1721
mi
from 98109
Saint Louis, MO
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Saint Petersburg, Florida 33713
2525
mi
from 98109
Saint Petersburg, FL
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San Antonio, Texas 78224
1787
mi
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San Antonio, TX
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Novo Nordisk Investigational Site
San Diego, California 92111
1065
mi
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San Diego, CA
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Sandy Springs, Georgia 30328
2172
mi
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Sandy Springs, GA
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Santa Barbara, California 93105
923
mi
from 98109
Santa Barbara, CA
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Suwanee, Georgia 30024
2180
mi
from 98109
Suwanee, GA
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Syracuse, New York 13210
2231
mi
from 98109
Syracuse, NY
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Tacoma, Washington 98405
26
mi
from 98109
Tacoma, WA
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Tallahassee, Florida 32308
2330
mi
from 98109
Tallahassee, FL
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Temecula, California 92591
1014
mi
from 98109
Temecula, CA
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Topeka, Kansas 66606
1455
mi
from 98109
Topeka, KS
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Novo Nordisk Investigational Site
Tucker, Georgia 30084
2182
mi
from 98109
Tucker, GA
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Tucson, Arizona 85704
1212
mi
from 98109
Tucson, AZ
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Tuscaloosa, Alabama 35406
2058
mi
from 98109
Tuscaloosa, AL
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Tustin, California 92780
988
mi
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Tustin, CA
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Vero Beach, Florida 32960
2633
mi
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Vero Beach, FL
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Vestavia Hills, Alabama 35209
2083
mi
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Vestavia Hills, AL
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Walnut Creek, California 94598
664
mi
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Walnut Creek, CA
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Warrenton, Virginia 20186
2293
mi
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Warrenton, VA
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West Palm Beach, Florida 33409
2692
mi
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West Palm Beach, FL
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