Cognitive Function After Treatment of Primary CNS Malignancy
| Status: | Recruiting |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 4 - Any |
| Updated: | 10/17/2018 |
| Start Date: | May 24, 2017 |
| End Date: | May 2021 |
| Contact: | Clinical Trials Referral Office |
| Email: | schneider.jessica@mayo.edu |
| Phone: | 855-776-0015 |
Observational Study Evaluating Neurocognitive Function in Patients With Primary CNS Malignancy Receiving Radiation Treatment to the Brain
In this study, the investigators propose to evaluate cognitive function and determine the
feasibility of neurocognitive assessment using a select CogState test battery in patients
with primary intracranial malignancies receiving photon- or proton-based cranial irradiation
with curative intent. The investigators will use the CogState software to quantify changes in
verbal learning, memory, and executive function over the initial months and years following
radiation treatment. Cognitive changes and temporal patterns of function will be compared to
baseline performance for each patient. Data regarding cognitive function, fatigue, quality of
life, and standard patient reported outcomes will be collected to characterize the daily
impact of treatment. In addition, observed outcomes will be correlated with dosimetry values,
radiation dose volumes, and anatomic dose distribution.
feasibility of neurocognitive assessment using a select CogState test battery in patients
with primary intracranial malignancies receiving photon- or proton-based cranial irradiation
with curative intent. The investigators will use the CogState software to quantify changes in
verbal learning, memory, and executive function over the initial months and years following
radiation treatment. Cognitive changes and temporal patterns of function will be compared to
baseline performance for each patient. Data regarding cognitive function, fatigue, quality of
life, and standard patient reported outcomes will be collected to characterize the daily
impact of treatment. In addition, observed outcomes will be correlated with dosimetry values,
radiation dose volumes, and anatomic dose distribution.
Inclusion Criteria:
- Age ≥ 4 years with primary CNS malignancy
- Able to use computer for assessment battery
- Receiving photon- or proton-based radiation for primary intracranial malignancy
- Demonstrates the capacity to sign informed consent
Exclusion Criteria:
- Patients with WHO Grade IV tumors
We found this trial at
1
site
200 First Street SW
Rochester, Minnesota 55905
Rochester, Minnesota 55905
507-284-2511
Phone: 855-776-0015
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
Click here to add this to my saved trials
