Efficacy and Safety of GSP 301 Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (SAR)

Inclusion Criteria:

- Males and non-pregnant females who are 12 years of age and older.

- Documented clinical history of SAR (for at least 2 years preceding the Screening Visit
[Visit 1]) with exacerbations (clinical evidence of active symptoms) for the relevant
seasonal allergen during the Fall or mountain cedar allergy seasons (e.g., ragweed or
mountain cedar pollen)

- A 12-hour rTNSS ≥8 out of a possible 12 and a congestion score ≥2 for the AM
assessment at the Screening Visit (Visit 1).

Exclusion Criteria:

- Pregnant or lactating women.

- History of anaphylaxis and/or other severe local reaction(s) to skin testing.

- History of positive test for HIV, Hepatitis B or Hepatitis C infection.

- Documented evidence of acute or significant chronic sinusitis or chronic purulent
postnasal drip.

- Subjects with an active pulmonary disorder or infection.

- Subjects with posterior subcapsular cataracts or glaucoma

- Plans to travel outside the known pollen area for the investigational site for 24
hours or longer during the last 7 days of the run-in period.