The MOTS (Medication Overuse Treatment Strategy) Trial



Status:Enrolling by invitation
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:21 - Any
Updated:4/6/2019
Start Date:January 9, 2017
End Date:April 30, 2021

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Determining the Optimal Treatment Strategy for Patients Who Have Chronic Migraine With Medication Overuse

There are two commonly used treatment strategies for treating patients who have chronic
migraine with medication overuse. This study will compare the outcomes amongst patients
randomized to one of the two treatment strategies.


Inclusion Criteria

- Adults, at least 21 years of age

- Chronic Migraine - diagnosed according to ICHD3beta criteria

- Medication Overuse - diagnosed according to ICHD3beta criteria

- Willingness to be randomized to either of the two treatment arms

- Willingness to maintain a headache diary

- Plan for follow-up care with the clinician

- No changes to migraine prophylactic therapy within the 4 weeks prior to randomization.

Exclusion Criteria

- Younger than 21 years of age

- Headache diagnoses other than chronic migraine with medication overuse; episodic
tension-type headache on 3 or fewer days per month is allowed

- Not willing to be randomized to either of the treatment arms

- Not willing to maintain a daily headache diary

- Not planning on follow-up care with the clinician

- In the opinion of the clinician, randomization to either treatment arm would be
considered unsafe (ex: pregnancy, immediate discontinuation

- Prisoners

- Diminished decision-making capacity which in the investigator's opinion would
interfere with the person's ability to provide informed consent and complete study
procedures.
We found this trial at
31
sites
Louisville, Kentucky 40207
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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1601 Northwest 12th Avenue
Miami, Florida 33136
(305) 243-6545
University of Miami Miller School of Medicine The University of Miami Leonard M. Miller School...
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Amherst, New York 14226
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Aurora, CO
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1153 Centre St
Boston, Massachusetts 02130
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Boston, MA
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1153 Centre St
Boston, Massachusetts 02130
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222 Piedmont Ave # 3200
Cincinnati, Ohio 45417
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318 East University Avenue
Cincinnati, Ohio 45417
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Dayton, OH
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3055 Roslyn Street
Denver, Colorado 80238
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107 East Oak Avenue
Flagstaff, Arizona 86001
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Flagstaff, AZ
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Glendale, AZ
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Greenwood Village, Colorado 80111
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3501 Johnson Street
Hollywood, Florida 33021
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Hollywood, FL
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205 North East Avenue
Jackson, Michigan 49201
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Jackson, MI
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Los Angeles, California 90033
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Morgantown, West Virginia 26506
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111 s South 11th Street
Philadelphia, Pennsylvania 19107
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5777 East Mayo Boulevard
Phoenix, Arizona 85054
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5777 East Mayo Boulevard
Phoenix, Arizona 85054
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140 Curry Hollow Road
Pittsburgh, Pennsylvania 15236
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Ridgeland, Mississippi 39157
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200 1st Street Southwest
Rochester, Minnesota 55905
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3862 Mexico Road
Saint Peters, Missouri 63303
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1138 Wilmington Avenue
Salt Lake City, Utah 84106
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65 Mario Capecchi Drive
Salt Lake City, Utah 84132
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501 Chipeta Way
Salt Lake City, Utah 84108
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13737 North 92nd Street
Scottsdale, Arizona 85260
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Springfield, Missouri 65807
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4235 Secor Road
Toledo, Ohio 43623
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