Study Of Asthma And Genetics In Patients To Be Treated With Fluticasone Propionate/Salmeterol Or Salmeterol Xinafoate



Status:Completed
Conditions:Asthma
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:12 - Any
Updated:2/4/2017
Start Date:October 2004
End Date:January 2007

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Trial Summary
Trial Overview
Inclusion Criteria

Randomized, Double-Blind Comparison of Advair 100/50 BID vs Salmeterol BID vs Albuterol QID in Subjects With ARG/ARG Genotype 12 Years of Age and Older With Presistent Asthma on Short-Acting Beta2-Agonists Alone

This study may last up to 36-38 weeks. Patients will visit the clinic 11 times. A blood
sample will be taken at Visit 1 to look at subjects' genes. Breathing tests will be done
during the study. Study medicines and procedures will be provided at no cost. Patients will
be treated with VENTOLIN (8 wks), ATROVENT (8 wks), then ADVAIR or SEREVENT (16 wks). ADVAIR
and SEREVENT are FDA approved for the treatment of asthma in patients 4 years of age and
older.

A Randomized, Parallel Group, Double-Blind, Comparative Trial Assessing Lung Function and
Other Measures of Asthma Control in Adults and Adolescents, at least 12 Years of Age, with
Persistent Asthma, Who Have Either a B16-Arg/Arg, a B16-Gly/Gly or a B-16 Arg/Gly Genotype
and are Treated With Fluticasone Propionate/Salmeterol DISKUS™ Combination Product 100/50mcg
or Salmeterol DISKUS 50 mcg BID

Inclusion criteria:

- Diagnosis of persistent asthma for 3 months.

- Use of short-acting beta-agonist medication like VENTOLIN.

Exclusion criteria:

- Hospitalization for asthma 6 months before study.

- Other serious diseases like congestive heart failure, uncontrolled hypertension, TB.

- Current use of inhaled or oral corticosteroids.
We found this trial at
74
sites
GSK Investigational Site
Chattanooga, Tennessee 37421
728
mi
from
Chattanooga, TN
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Asheville, North Carolina 28803
859
mi
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Asheville, NC
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GSK Investigational Site
Atlanta, Georgia 30341
801
mi
from
Atlanta, GA
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GSK Investigational Site
Baltimore, Maryland 21201
1148
mi
from
Baltimore, MD
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GSK Investigational Site
Bayshore, New York 11706
?
mi
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Bayshore, NY
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GSK Investigational Site
Bellingham, Washington 98225
1445
mi
from
Bellingham, WA
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GSK Investigational Site
Boston, Massachusetts 02115
1444
mi
from
Boston, MA
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GSK Investigational Site
Charleston, South Carolina 29425
1063
mi
from
Charleston, SC
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GSK Investigational Site
Chicago, Illinois 60611
611
mi
from
Chicago, IL
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GSK Investigational Site
Colorado Springs, Colorado 80910
383
mi
from
Colorado Springs, CO
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GSK Investigational Site
Columbia, Missouri 65201
308
mi
from
Columbia, MO
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GSK Investigational Site
Coral Gables, Florida 33134
1318
mi
from
Coral Gables, FL
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GSK Investigational Site
Corsicana, Texas 75110
398
mi
from
Corsicana, TX
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GSK Investigational Site
Covington, Louisiana 70433
668
mi
from
Covington, LA
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GSK Investigational Site
Dallas, Texas 75230
340
mi
from
Dallas, TX
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GSK Investigational Site
Denver, Colorado 80206
407
mi
from
Denver, CO
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GSK Investigational Site
El Paso, Texas 79915
638
mi
from
El Paso, TX
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GSK Investigational Site
Fort Worth, Texas 76104
348
mi
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Fort Worth, TX
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GSK Investigational Site
Fresno, California 93720
1205
mi
from
Fresno, CA
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GSK Investigational Site
Fullerton, California 92835
1154
mi
from
Fullerton, CA
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GSK Investigational Site
Hackensack, New Jersey 07601
1285
mi
from
Hackensack, NJ
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GSK Investigational Site
Houston, Texas 77030
572
mi
from
Houston, TX
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GSK Investigational Site
Huntington Beach, California 92647
1162
mi
from
Huntington Beach, CA
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GSK Investigational Site
Indianapolis, Indiana 46202
643
mi
from
Indianapolis, IN
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GSK Investigational Site
Inglewood, California 90301
1176
mi
from
Inglewood, CA
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GSK Investigational Site
Irvine, California 92697
1156
mi
from
Irvine, CA
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GSK Investigational Site
Jackson, Mississippi 39202
572
mi
from
Jackson, MS
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GSK Investigational Site
Jacksonville, Florida 32207
1058
mi
from
Jacksonville, FL
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GSK Investigational Site
Kerrville, Texas 78028
537
mi
from
Kerrville, TX
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GSK Investigational Site
Kirkland, Washington 98034
1407
mi
from
Kirkland, WA
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GSK Investigational Site
Knoxville, Tennessee 37916
777
mi
from
Knoxville, TN
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GSK Investigational Site
Lakewood, Colorado 80228
417
mi
from
Lakewood, CO
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GSK Investigational Site
Lawrenceville, Georgia 30046
816
mi
from
Lawrenceville, GA
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GSK Investigational Site
Lilburn, Georgia 30047
810
mi
from
Lilburn, GA
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GSK Investigational Site
Little Rock, Arkansas 72205
368
mi
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Little Rock, AR
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GSK Investigational Site
Long Beach, California 90813
1172
mi
from
Long Beach, CA
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GSK Investigational Site
Los Angeles, California 90025
1179
mi
from
Los Angeles, CA
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GSK Investigational Site
Madison, Wisconsin 53792
574
mi
from
Madison, WI
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GSK Investigational Site
Medford, Oregon 97504
1357
mi
from
Medford, OR
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GSK Investigational Site
Metairie, Louisiana 70006
688
mi
from
Metairie, LA
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GSK Investigational Site
Miami, Florida 33136
1320
mi
from
Miami, FL
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GSK Investigational Site
Milwaukee, Wisconsin 53215
632
mi
from
Milwaukee, WI
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GSK Investigational Site
Mobile, Alabama 36617
737
mi
from
Mobile, AL
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GSK Investigational Site
Nairobi, 00200
?
mi
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Nairobi,
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GSK Investigational Site
Nashville, Tennessee 37203
618
mi
from
Nashville, TN
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GSK Investigational Site
New York, New York 10032
1290
mi
from
New York, NY
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GSK Investigational Site
Newark, New Jersey 07112
1276
mi
from
Newark, NJ
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GSK Investigational Site
North Dartmouth, Massachusetts 02747
1446
mi
from
North Dartmouth, MA
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GSK Investigational Site
Oklahoma City, Oklahoma 73112
155
mi
from
Oklahoma City, OK
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GSK Investigational Site
Orange, California 92868
1154
mi
from
Orange, CA
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GSK Investigational Site
Orangeburg, South Carolina 29118
995
mi
from
Orangeburg, SC
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GSK Investigational Site
Orlando, Florida 32806
1144
mi
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Orlando, FL
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GSK Investigational Site
Overland Park, Kansas 66210
187
mi
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Overland Park, KS
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GSK Investigational Site
Papillion, Nebraska 68046
253
mi
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Papillion, NE
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GSK Investigational Site
Philadelphia, Pennsylvania 19104
1223
mi
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Philadelphia, PA
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GSK Investigational Site
Richmond, Virginia 23298
1113
mi
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Richmond, VA
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GSK Investigational Site
Rochester, New York 14642
1121
mi
from
Rochester, NY
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GSK Investigational Site
San Antonio, Texas 78258
561
mi
from
San Antonio, TX
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GSK Investigational Site
Sarasota, Florida 34232
1145
mi
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Sarasota, FL
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GSK Investigational Site
Shreveport, Louisiana 71103
429
mi
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Shreveport, LA
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GSK Investigational Site
South Burlington, Vermont 05403
1358
mi
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South Burlington, VT
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GSK Investigational Site
South Miami, Florida 33143
1320
mi
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South Miami, FL
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GSK Investigational Site
Spartanburg, South Carolina 29303
902
mi
from
Spartanburg, SC
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GSK Investigational Site
Spring Valley, California 91978
1248
mi
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Spring Valley, CA
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GSK Investigational Site
St. Louis, Missouri 63110
415
mi
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St. Louis, MO
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GSK Investigational Site
Stockton, California 95207
1278
mi
from
Stockton, CA
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GSK Investigational Site
Tallahassee, Florida 32308
924
mi
from
Tallahassee, FL
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GSK Investigational Site
Tampa, Florida 33612
1112
mi
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Tampa, FL
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GSK Investigational Site
Upland, Pennsylvania 19013
1213
mi
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Upland, PA
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GSK Investigational Site
Warrensburg, Missouri 64093
232
mi
from
Warrensburg, MO
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GSK Investigational Site
Waterbury, Connecticut 06708
1337
mi
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Waterbury, CT
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GSK Investigational Site
West Allis, Wisconsin 53227
628
mi
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West Allis, WI
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GSK Investigational Site
Wheat Ridge, Colorado 80033
416
mi
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Wheat Ridge, CO
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GSK Investigational Site
Winston-Salem, North Carolina 27103
971
mi
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Winston-Salem, NC
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