Combination Pharmacotherapy for Smoking Cessation Among Methadone Patients

This is a one-arm, open label pilot study of MMT patients to determine whether bupropion,
nicotine replacement therapy, and behavioral counseling is a feasible and potentially
effective intervention for smoking cessation. The smoking behaviors of participants will be
be followed for 6 months post quit-date to determine effect-size estimates for a future,
large scale trial.

Inclusion Criteria:

- Patients in long-term methadone maintenance treatment

- Patient smokes at least 10 cigarettes per day, are stable on their use of methadone
(phase 2 or higher treatment), smoked for at least 1 year, be willing to participate
for 6 months, and not have used bupropion or nicotine replacement therapy for 6
months

Exclusion Criteria:

- Patients who use prescription drug regimens that might affect methadone or bupropion
metabolism

- Patients with cardiovascular disease, asthma, COPD

- Patients who are pregnant or breastfeeding

- Patients with regular use of alcohol, other illicit drugs, or other types of tobacco
(chewing or pipe for example)