Myelofibrosis and Essential Thrombocythemia Observational Study (MOST)



Status:Recruiting
Conditions:Hematology
Therapuetic Areas:Hematology
Healthy:No
Age Range:18 - Any
Updated:2/8/2019
Start Date:December 2016
End Date:March 2022
Contact:MOST Study (Incyte Corporation)
Email:IncyteMFandETStudy@syneoshealth.com

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Prospective, Longitudinal, Non-Interventional Study of Disease Burden and Treatment of Patients With Low-Risk Myelofibrosis (MF) or High-Risk Essential Thrombocythemia (ET) or ET Patients Receiving ET-Directed Therapy

The purpose of this prospective, longitudinal, noninterventional study is to describe
clinical characteristics, evolution of disease burden, and treatment patterns in patients
with select subcategories of essential thrombocythemia (ET) or myelofibrosis (MF).


Inclusion Criteria:

- MF cohort: Diagnosis of MF and low-risk using DIPSS risk categorization OR
intermediate-1 risk by DIPSS by reason of age alone.

- ET cohort: Diagnosis of ET and age ≥ 60 years OR history of thromboembolic events OR
currently receiving ET-directed therapy (eg, hydroxyurea, anagrelide, interferon,
busulfan, ruxolitinib, etc).

- Willing and able to provide written informed consent.

- Willing and able to complete patient assessment questionnaires either alone or with
minimal assistance from a caregiver and/or trained site personnel.

- Under the supervision of a physician for the current care of MF or ET.

Exclusion Criteria:

- Individuals who are participating in blinded investigational drug studies.

- Individuals who are participating in Incyte investigational/interventional drug trials
(company- or investigator-sponsored studies) until they have completed the 30-day end
of study visit.

- Life expectancy ≤ 6 months.

- Diagnosis of secondary acute myeloid leukemia, myelodysplastic syndrome, chronic
myelogenous leukemia, or secondary thrombocytosis.
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