A Study of ALX148 in Patients With Advanced Solid Tumors and Lymphoma



Status:Recruiting
Conditions:Cancer, Cancer, Cancer, Cancer, Cancer, Lymphoma, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:8/10/2018
Start Date:February 3, 2017
End Date:December 2019
Contact:Sophia Randolph, MD, PhD
Email:info@alxoncology.com
Phone:650-466-7125

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A Phase 1, Dose Escalation Study of ALX148 in Patients With Advanced Solid Tumors and Lymphoma

A phase 1, dose escalation study of ALX148 in patients with advanced solid tumors and
lymphoma

This phase 1 clinical study (AT148001) is an open-label, multi-center, multiple-dose,
dose-escalation, safety, PK, and PD study of ALX148. The phase 1 protocol will have 2 parts:
a single agent dose escalation phase (Part 1) and a combination therapy phase (Part 2). Part
2 will include an initial dose escalation portion followed by a dose expansion portion.
Approximately 142 adult patients are expected to be enrolled in the study.

Inclusion Criteria:

- Histological or cytological diagnosis of advanced/metastatic solid tumor malignancy;
or relapsed or refractory Non-Hodgkin lymphoma for whom no standard therapy is
available..

- Adequate Bone Marrow Function.

- Adequate Renal & Liver Function.

- Adequate Performance Status

Exclusion Criteria:

- Patients with known symptomatic CNS metastases or lepotomeningeal disease requiring
steroids.

- Previous high-dose chemotherapy requiring allogenic stem cell rescue.

- Prior treatment with a CD47 or signal regulatory protein (SIRP) alpha targeting agent.
We found this trial at
7
sites
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Phone: 617-632-5053
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-4000
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Phone: 206-606-7551
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, WA
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Denver, Colorado 80291
Principal Investigator: Wells Messersmith, MD, FACP
Phone: 720-848-0523
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Grand Rapids, Michigan 49503
Principal Investigator: Nehal Lakhani, MD, PhD
Phone: 616-954-5554
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Grand Rapids, MI
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New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Patricia LoRusso, DO
Phone: 203-737-5228
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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New Haven, CT
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Seongnam,
Phone: 82-31-787-7003
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Seongnam,
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