Intergenerational Blood Pressure Study
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 3 - Any |
| Updated: | 3/1/2017 |
| Start Date: | September 2014 |
| End Date: | June 2019 |
| Contact: | Jacquely Y Taylor, PhD |
| Email: | jacquelyn.taylor@yale.edu |
| Phone: | 203-737-2364 |
Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure
This project, the Intergenerational Blood Pressure Study, is a 5 year research study funded
by the National Institutes of Health/National Institute of Nursing Research and led by the
Yale University School of Nursing and The Consultation Center at the Yale University School
of Medicine, Department of Psychiatry in partnership with Head Start programs across CT. The
investigators seek to reduce hypertension health disparities among underserved Black/African
American children and their mothers by conducting community-based research to better
understand the genetic, psychological, and environmental factors that may contribute to high
blood pressure.
by the National Institutes of Health/National Institute of Nursing Research and led by the
Yale University School of Nursing and The Consultation Center at the Yale University School
of Medicine, Department of Psychiatry in partnership with Head Start programs across CT. The
investigators seek to reduce hypertension health disparities among underserved Black/African
American children and their mothers by conducting community-based research to better
understand the genetic, psychological, and environmental factors that may contribute to high
blood pressure.
This study will examine: (1) the impact of (GXE) genetic and psychological environmental
factors (discrimination, depression, and parenting behaviors) on the health of African
American (AA) children aged 3 through 5 years and (2) the GXE risk for hypertension (HTN) in
AA women and children. The overall goal of this project is to delineate the psychobiological
(GXE interaction) mechanisms through which AA mothers' perceived racial discrimination,
mental health, and parenting behavior affect their own and their young children's blood
pressure (BP) over time. The research will examine both genetic (candidate gene and
epigenetic effects) and psychological (maternal perceived racial discrimination, mental
health, and parenting behavior) interaction effects on BP on this population. The
investigators will employ a psychobiological approach by: utilizing psychological and
biological assessments using a longitudinal cohort research design, a 2-step candidate gene
and epigenetic methodology, and use of ancestry informative markers to account for
population stratification admixture to explore GXE interactions on BP in AA mothers and
children. Data analysis for the study will be conducted using multiple mixed modeling,
cross-validation, and false discovery rate methods. The investigators will enroll 250 AA
children aged 3 through 5 years and their (n=250) mothers/maternal caregivers. The
investigators will assess mother and child factors every six months for 2 years. The
investigators propose the following: Aim 1: Examine the GXE interaction and epigenetic
effects of mothers' perceived racial discrimination and its influence on BP over a period of
two years. Aim 2: Examine the GXE interaction and epigenetic effects of mothers' mental
health status [symptoms of depression] and its influence on BP over a period of two years.
Aim 3: Examine the GXE interaction and epigenetic effects of mothers' parenting behavior and
its influence on BP over a period of two years. This project supports the National Institute
of Nursing Research mission "to promote and improve the health of individuals, families,
communities, and populations" by conducting basic research on the health and illness of
women and young children. The proposed research extends nursing science by integrating the
biological (genetics) and behavioral (psychology) components that can inform the combination
of multi-level factors that contribute to AAs having the highest incidence of HTN in the US.
Findings from this project can contribute to developing interventions that address genetic
and psychological factors to reduce these risks for HTN.
factors (discrimination, depression, and parenting behaviors) on the health of African
American (AA) children aged 3 through 5 years and (2) the GXE risk for hypertension (HTN) in
AA women and children. The overall goal of this project is to delineate the psychobiological
(GXE interaction) mechanisms through which AA mothers' perceived racial discrimination,
mental health, and parenting behavior affect their own and their young children's blood
pressure (BP) over time. The research will examine both genetic (candidate gene and
epigenetic effects) and psychological (maternal perceived racial discrimination, mental
health, and parenting behavior) interaction effects on BP on this population. The
investigators will employ a psychobiological approach by: utilizing psychological and
biological assessments using a longitudinal cohort research design, a 2-step candidate gene
and epigenetic methodology, and use of ancestry informative markers to account for
population stratification admixture to explore GXE interactions on BP in AA mothers and
children. Data analysis for the study will be conducted using multiple mixed modeling,
cross-validation, and false discovery rate methods. The investigators will enroll 250 AA
children aged 3 through 5 years and their (n=250) mothers/maternal caregivers. The
investigators will assess mother and child factors every six months for 2 years. The
investigators propose the following: Aim 1: Examine the GXE interaction and epigenetic
effects of mothers' perceived racial discrimination and its influence on BP over a period of
two years. Aim 2: Examine the GXE interaction and epigenetic effects of mothers' mental
health status [symptoms of depression] and its influence on BP over a period of two years.
Aim 3: Examine the GXE interaction and epigenetic effects of mothers' parenting behavior and
its influence on BP over a period of two years. This project supports the National Institute
of Nursing Research mission "to promote and improve the health of individuals, families,
communities, and populations" by conducting basic research on the health and illness of
women and young children. The proposed research extends nursing science by integrating the
biological (genetics) and behavioral (psychology) components that can inform the combination
of multi-level factors that contribute to AAs having the highest incidence of HTN in the US.
Findings from this project can contribute to developing interventions that address genetic
and psychological factors to reduce these risks for HTN.
Inclusion Criteria:
Mothers must:
- Self-identify as Black/African American
- Be 21 years or older
- Have a 3-5 year old biological child
- Not be impaired by a though disorder, psychosis, or mania
- Confirm that their child will be able to provide saliva sample for DNA
- Be English-speaking
Exclusion Criteria:
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