Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/27/2019
Start Date:October 3, 2016
End Date:October 2021
Contact:Nancy Lee, MD
Phone:212-639-3341

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A Phase II Randomized Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Unilateral Head and Neck Cancer

Compared to IMRT, PBRT is thought to give less radiation exposure to the surrounding healthy
tissues. It is possible that side effect rates with PBRT will be lower or the same compared
to IMRT, but this has not been well studied to date. Although both of these radiation
therapies have been used in the past to treat head and neck cancer, this research study will
compare the effects of these two different radiation treatment modalities with each other to
see whether PBRT is better, the same or worse than IMRT.


Inclusion Criteria:

- Age greater than or equal to 18.

- Histopathologically confirmed diagnosis of one the following cancer types:

- Salivary gland cancer without the presence of extracapsular extension and/or
positive surgical margin.

- Skin cancer

- Melanoma

- Patients must be a candidate for ipsilateral radiation therapy.

- Karnofsky performance status ≥70.

- Negative pregnancy test for women of childbearing potential (<51 years of age) as per
institutional policy.

Exclusion Criteria:

- Any prior head or neck irradiation.

- Physician recommendation of bilateral neck radiation.

- Non-resectable disease

- Physician recommendation of mucosal radiation

- Use of chemotherapy
We found this trial at
9
sites
500 Westchester Avenue
Harrison, New York 10604
Phone: 212-639-3341
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Basking Ridge, New Jersey 07920
Phone: 212-639-3341
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Commack, New York 11725
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Middletown, New Jersey 07748
Phone: 212-639-3341
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225 Summit Avenue
Montvale, New Jersey 07645
Phone: 212-639-3341
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Nancy Lee, MD
Phone: 212-639-3341
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Rochester, Minnesota 55905
Principal Investigator: Robert Foote, MD
Phone: 507-284-2511
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Rochester, MN
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Rockville Centre, New York 11570
Phone: 212-639-3341
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Rockville Centre, NY
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Uniondale, New York 11553
Phone: 212-639-3341
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Uniondale, NY
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