Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/22/2018 |
| Start Date: | October 25, 2016 |
| End Date: | September 28, 2021 |
A Phase III, Randomized, Open Label Trial of Nivolumab in Combination With Ipilimumab Versus Pemetrexed With Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma
The purpose of this study is to test the effectiveness and tolerability of the combination of
Nivolumab and Ipilimumab compared to Pemetrexed and Cisplatin or Carboplatin in patients with
unresectable pleural mesothelioma.
Nivolumab and Ipilimumab compared to Pemetrexed and Cisplatin or Carboplatin in patients with
unresectable pleural mesothelioma.
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com
Inclusion Criteria:
- Males and Females at least 18 years of age
- Histologically confirmed pleural malignant mesothelioma not eligible for curative
surgery
- ECOG Performance status of 0 or 1
- Available tumor sample for testing
- Acceptable blood work
Exclusion Criteria:
- Primitive peritoneal, pericardial and tunica vaginalis testis mesotheliomas
- Prior chemotherapy for pleural mesothelioma
- Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2 oranti-CTLA-4 antibody
- History of other malignancy unless the subject has been disease-free for at least 3
years
- Active, untreated central nervous system (CNS) metastasis
Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
15
sites
5801 South Ellis Avenue
Chicago, Illinois 60637
Chicago, Illinois 60637
773.702.1234
Phone: 773-834-1472
University of Chicago One of the world's premier academic and research institutions, the University of...
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Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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575 Coal Valley Road
Jefferson Hills, Pennsylvania 15025
Jefferson Hills, Pennsylvania 15025
Phone: 412-578-4639
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West Virginia University West Virginia University, founded in 1867, has a long and rich history...
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Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Phone: 646-888-4656
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-662-9801
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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