Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer



Status:Recruiting
Conditions:Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/12/2018
Start Date:October 4, 2016
End Date:October 6, 2022
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
Email:Clinical.Trials@bms.com

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A Randomized, Multicenter, Open-Label, Phase 3 Study of Nivolumab Plus Ipilimumab or Nivolumab in Combination With Oxaliplatin Plus Fluoropyrimidine Versus Oxaliplatin Plus Fluoropyrimidine in Subjects With Previously Untreated Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer

The main purpose of this study is to compare how long patients with gastric or
gastroesophageal junction cancer live after receiving nivolumab and ipilimumab or nivolumab
and chemotherapy compared with patients receiving chemotherapy alone.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Male or Female at least 18 years of age

- Must have gastric cancer or gastroesophageal junction cancer that cannot be operated
on and that is advanced or has spread out

- Did not receive neoadjuvant or adjuvant treatment (chemotherapy, radiotherapy, or
both) for their disease within the last 6 months

- Must have full activity or, if limited, must be able to walk and carry out light
activities such as light house work or office work

- Must agree to provide tumor tissue sample, either from a previous surgery or biopsy
within 6 months or fresh, prior to the start of treatment in this study

Exclusion Criteria:

- Presence of tumor cells in the brain or spinal cord that have not been treated

- Active known or suspected autoimmune disease

- Any serious or uncontrolled medical disorder or active infection

- Known history of positive test for human immunodeficiency virus (HIV) or known
acquired immunodeficiency syndrome (AIDS)

- Any positive test result for hepatitis B or C indicating acute or chronic infection

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
28
sites
Aurora, Colorado 80045
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Phone: 617-975-7462
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Phone: 216-636-2690
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Cleveland, OH
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Allentown, Pennsylvania 18105
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Allentown, PA
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Arlington Heights, Illinois 60005
Phone: 281-863-6403
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Arlington Heights, IL
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Baltimore, Maryland 21231
Phone: 410-502-3474
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Baltimore, MD
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Bedford, Texas 76022
Phone: 281-863-6403
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Bedford, TX
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Phone: 617-632-3773
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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2061 Avenida Caseros
Capital Federal, Buenos Aires C1264
Phone: +541143043202
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Capital Federal,
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303 East Superior Street
Chicago, Illinois 60611
Phone: 312-695-4781
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Chicago, IL
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11100 Euclid Ave
Cleveland, Ohio 44106
(216) 844-1000
Phone: 216-844-6003
University Hospitals of Cleveland The history of University Hospitals Case Medical Center is linked to...
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Dallas, Texas 75230
Phone: 281-863-6403
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Dallas, Texas 75246
Phone: 281-863-6403
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Denver, Colorado 80218
Phone: 281-863-6403
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Eugene, Oregon 97401
Phone: 281-863-6403
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Eugene, OR
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Fort Myers, Florida 33916
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Fort Myers, FL
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1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Houston, TX
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
Phone: 323-865-0463
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Marietta, Georgia 30060
Phone: 770-281-5124
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Marietta, GA
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Miami, Florida 33176
Phone: 281-863-6403
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Miami, FL
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Nashville, TN
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 646-888-4186
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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Newport News, Virginia 23606
Phone: 281-863-6403
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Newport News, VA
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PIttsburgh, Pennsylvania 15212
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Plano, Texas 75075
Phone: 281-863-6403
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Saint Petersburg, Florida 33705
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Saint Petersburg, FL
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San Francisco, California 94110
Phone: 415-600-3472
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 687-7695
Georgetown University Medical Center Georgetown University Medical Center is committed to excellence in research, education...
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Washington,
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