Filgotinib Versus Placebo in Adults With Active Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Biologic Disease-modifying Anti-rheumatic Drug(s) (DMARDs) Treatment



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:3/20/2019
Start Date:July 27, 2016
End Date:June 26, 2018

Use our guide to learn which trials are right for you!

A Randomized, Double-blind, Placebo-controlled, Multicenter, Phase 3 Study to Assess the Efficacy and Safety of Filgotinib Administered for 24 Weeks in Combination With Conventional Synthetic Disease-modifying Anti-rheumatic Drug(s) (csDMARDs) to Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic DMARD(s) Treatment

The primary objective of this study is to evaluate the effects of filgotinib versus placebo
in adults with active rheumatoid arthritis (RA) who have an inadequate response to biologic
disease-modifying anti-rheumatic drug(s) (DMARDs) treatment.


Key Inclusion Criteria:

- Have a diagnosis of RA (2010 ACR/EULAR criteria for RA), and are ACR functional class
I-III.

- Have ≥ 6 swollen joints (from a swollen joint count based on 66 joints (SJC66)) and ≥6
tender joints (from a tender joint count based on 68 joints (TJC68)) at screening and
Day 1

- Ongoing treatment with a stable prescription of 1 or 2 csDMARDs

- Have received at least one biologic disease modifying antirheumatic drug (bDMARD) for
the treatment of RA to which they have had an inadequate response or intolerance

Key Exclusion Criteria:

- Previous treatment with any janus kinase (JAK) inhibitor

NOTE: Other protocol Inclusion/ Exclusion criteria may apply.
We found this trial at
56
sites
2258
mi
from 91732
Frederick, MD
Click here to add this to my saved trials
2319
mi
from 91732
Aventura, FL
Click here to add this to my saved trials
1423
mi
from 91732
Beaumont, TX
Click here to add this to my saved trials
2434
mi
from 91732
Brooklyn, NY
Click here to add this to my saved trials
6113
mi
from 91732
Buenos Aires,
Click here to add this to my saved trials
Charleston, South Carolina 29412
2184
mi
from 91732
Charleston, SC
Click here to add this to my saved trials
Charlotte, North Carolina 28207
2102
mi
from 91732
Charlotte, NC
Click here to add this to my saved trials
2104
mi
from 91732
Columbia, SC
Click here to add this to my saved trials
1293
mi
from 91732
Corpus Christi, TX
Click here to add this to my saved trials
7
mi
from 91732
Covina, CA
Click here to add this to my saved trials
2185
mi
from 91732
Cumberland, MD
Click here to add this to my saved trials
2180
mi
from 91732
Debary, FL
Click here to add this to my saved trials
1924
mi
from 91732
Decatur, GA
Click here to add this to my saved trials
1966
mi
from 91732
Detroit, MI
Click here to add this to my saved trials
1807
mi
from 91732
Elizabethtown, KY
Click here to add this to my saved trials
2420
mi
from 91732
Freehold, NJ
Click here to add this to my saved trials
363
mi
from 91732
Gilbert, AZ
Click here to add this to my saved trials
Greenville, North Carolina 27834
2290
mi
from 91732
Greenville, NC
Click here to add this to my saved trials
1676
mi
from 91732
Hattiesburg, MS
Click here to add this to my saved trials
64
mi
from 91732
Hemet, CA
Click here to add this to my saved trials
1785
mi
from 91732
Huntsville, AL
Click here to add this to my saved trials
2127
mi
from 91732
Jacksonville, FL
Click here to add this to my saved trials
1339
mi
from 91732
Kansas City, KS
Click here to add this to my saved trials
99
mi
from 91732
La Jolla, CA
Click here to add this to my saved trials
2515
mi
from 91732
Lebanon, NH
Click here to add this to my saved trials
1881
mi
from 91732
Lexington, KY
Click here to add this to my saved trials
1254
mi
from 91732
Lincoln, NE
Click here to add this to my saved trials
1586
mi
from 91732
Memphis, TN
Click here to add this to my saved trials
1235
mi
from 91732
Mesquite, TX
Click here to add this to my saved trials
2321
mi
from 91732
Miami, FL
Click here to add this to my saved trials
2025
mi
from 91732
Middleburg Heights, OH
Click here to add this to my saved trials
Myrtle Beach, South Carolina 29572
2234
mi
from 91732
Myrtle Beach, SC
Click here to add this to my saved trials
1164
mi
from 91732
Oklahoma City, OK
Click here to add this to my saved trials
2121
mi
from 91732
Orangeburg, SC
Click here to add this to my saved trials
2182
mi
from 91732
Orlando, FL
Click here to add this to my saved trials
97
mi
from 91732
Palm Desert, CA
Click here to add this to my saved trials
329
mi
from 91732
Palo Alto, CA
Click here to add this to my saved trials
2375
mi
from 91732
Philadelphia, PA
Click here to add this to my saved trials
1227
mi
from 91732
Plano, TX
Click here to add this to my saved trials
2311
mi
from 91732
Plantation, FL
Click here to add this to my saved trials
2113
mi
from 91732
Port Richey, FL
Click here to add this to my saved trials
31
mi
from 91732
Riverside, CA
Click here to add this to my saved trials
1975
mi
from 91732
Saint Clair Shores, MI
Click here to add this to my saved trials
1573
mi
from 91732
Saint Louis, MO
Click here to add this to my saved trials
Salisbury, North Carolina 28144
2118
mi
from 91732
Salisbury, NC
Click here to add this to my saved trials
1188
mi
from 91732
San Antonio, TX
Click here to add this to my saved trials
2426
mi
from 91732
Toms River, NJ
Click here to add this to my saved trials
1253
mi
from 91732
Tulsa, OK
Click here to add this to my saved trials
1666
mi
from 91732
Tupelo, MS
Click here to add this to my saved trials
20
mi
from 91732
Upland, CA
Click here to add this to my saved trials
49
mi
from 91732
Victorville, CA
Click here to add this to my saved trials
1376
mi
from 91732
Webster, TX
Click here to add this to my saved trials
7
mi
from 91732
Whittier, CA
Click here to add this to my saved trials
1182
mi
from 91732
Wichita, KS
Click here to add this to my saved trials
2540
mi
from 91732
Worcester, MA
Click here to add this to my saved trials
2331
mi
from 91732
Wyomissing, PA
Click here to add this to my saved trials