Safety Study for Treatment of Wet Macular Degeneration Using the TheraSight(TM) Ocular Brachytherapy System

Conditions:Cancer, Cardiology, Ocular
Therapuetic Areas:Cardiology / Vascular Diseases, Oncology, Ophthalmology
Age Range:50 - Any
Start Date:October 2004
Contact:Theragenics Corporation

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A Safety and Feasibility Study of the TheraSight(TM) Ocular Brachytherapy System for Treatment of Age-Related Macular Degeneration

The study will investigate the safety and feasibility of using the TheraSight(TM)
Brachytherapy System for treatment of wet age-related macular degeneration (AMD).

This is a multi-center randomized study of three doses of radiation (assigned 1:1:1)
delivered by the TheraSight(TM) Brachytherapy System in participants with choroidal
neovascularization (CNV) secondary to wet (exudative) AMD. Each participant receives a
single dose of radiation delivered by one-time only brachytherapy. Participants are followed
for three years after the radiation treatment.

Inclusion Criteria:

- Age 50 years or older.

- Active primary or recurrent subfoveal CNV secondary to AMD with minimally classic or
occult lesion, where an active lesion is defined as one or more of the following:

a) An increase > 10% in lesion size (greatest linear dimension) on screening
fluorescein angiography compared to previous fluorescein angiography no more than 180
days preceding screening visit

- b) Subretinal hemorrhage associated with CNV within 90 days of screening visit.

- c) Visual acuity loss > 1 Snellen line in screening visual acuity compared to
previous visual acuity no more than 180 days preceding screening

- Lesion < 6 mm greatest linear dimension (GLD)

- Submacular blood must comprise less than 75% of the total lesion

- Subretinal fibrosis must comprise less than 25% of the total lesion

- Study eye best-corrected vision of 20/100 or poorer measured on an ETDRS chart (< 48
letters correct)

- Fellow eye best-corrected vision that is at least one line better on an ETDRS chart
than the best-corrected vision of the study eye

- HbA1c < 6%

- Read and signed informed consent

Exclusion Criteria:

- Prior AMD therapy treatment, including but not limited to laser and photodynamic

- Current or planned participation in the next 180 days in other experimental trials
involving treatment of neovascular AMD in the study eye, ocular devices, or trials
involving treatment for ocular conditions other than AMD.

- Prior ophthalmic surgery for the study eye other than cataract extraction and/or
capsulotomy. A minimum interval of 180 days must elapse between cataract extraction
or capsulotomy and study enrollment.

- Likely need for cataract surgery in study eye during the 180 days following
TheraSight(TM) System treatment.

- Presence of other eye diseases that could compromise visual acuity in the study eye
or that, in the clinical judgment of the evaluating study ophthalmologist, might
create special risk for the study participant.

- CNV due to other causes such as ocular histoplasmosis or pathologic myopia.

- Endstage fibrotic disciform lesions.

- Diabetes requiring diet modification, or medication, or insulin.

- Current history of malignancy (except participants having basal cell carcinoma that
was treated successfully, or other malignancy operated on or treated and in remission
for five years prior to inclusion in the trial).

- Hypertensive retinopathy.

- Major cardiovascular or cerebrovascular event within the last year; examples include
congestive heart failure, myocardial infarction, and stroke.

- Inability to complete follow-up.

- Allergy to fluorescein dye.

- Previous radiation to the study eye.

- Pregnancy at time of surgical procedure.
We found this trial at
Newark, New Jersey
Newark, NJ
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Atlanta, Georgia
Atlanta, GA
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Augusta, Georgia
Augusta, GA
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Boston, Massachusetts
Boston, MA
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Indianapolis, Indiana
Indianapolis, IN
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Raleigh / Durham, North Carolina
Raleigh / Durham, NC
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