An Investigational Immuno-therapy Trial of Pomalidomide and Low-dose Dexamethasone With or Without Elotuzumab to Treat Refractory and Relapsed and Refractory Multiple Myeloma (ELOQUENT-3)



Status:Active, not recruiting
Conditions:Blood Cancer, Hematology, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:9/27/2018
Start Date:March 16, 2016
End Date:April 22, 2019

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An Open Label, Randomized Phase 2 Trial of Pomalidomide/Dexamethasone With or Without Elotuzumab in Relapsed and Refractory Multiple Myeloma (ELOQUENT-3)

The purpose of this study is to determine if adding Elotuzumab to Pomalidomide and low-dose
dexamethasone is a more effective treatment of relapsed and refractory multiple myeloma
compared to pomalidomide and low-dose dexamethasone by itself.


For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- ≥ 2 prior lines of therapy which must have included at least 2 consecutive cycles of
lenalidomide and a proteosome inhibitor alone or in combination

- Documented refractory or relapsed and refractory multiple myeloma

- Refractory to proteosome inhibitor and lenalidomide, and to last treatment

- Relapsed and refractory patients must have achieved at least a partial response to
previous treatment with proteosome inhibitor or lenalidomide, or both, but progressed
within 6 months, and were refractory to their last treatment

- Measurable disease at screening

- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2

Exclusion Criteria:

- Active plasma cell leukemia

- Prior treatment with pomalidomide

- Unable to tolerate thromboembolic prophylaxis while on the study

- Prior autologous stem cell transplant within 12 weeks

- Known Human Immunodeficiency Virus (HIV) infection or active hepatitis A, B, or C
We found this trial at
13
sites
Seattle, Washington 98104
(206) 543-2100
Phone: 206-288-1286
Univ of Washington Founded in 1861 by a private gift of 10 acres in what...
961
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Seattle, WA
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Atlanta, Georgia 30322
1922
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Atlanta, GA
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Boston, Massachusetts 02115
Phone: 617-632-2412
2578
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Boston, MA
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Boston, Massachusetts 02215
2578
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Boston, MA
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Charlotte, North Carolina 28203
2101
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Charlotte, NC
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Phone: 312-942-5083
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
1726
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Chicago, IL
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Greenville, South Carolina 29601
Phone: 864-603-6212
2018
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Greenville, SC
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Indianapolis, Indiana 46254
Phone: 317-716-0323
1787
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Indianapolis, IN
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Knoxville, Tennessee 37920
1925
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Knoxville, TN
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Ogden, Utah 84403
Phone: 801-387-7166
592
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Ogden, UT
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Pittsburgh, Pennsylvania 15240
Phone: 412-360-6230
2117
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Pittsburgh, PA
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Rochester, New York 14621
Phone: 585-922-9358
2246
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Rochester, NY
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South Brisbane, Queensland 4101
7199
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South Brisbane,
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