The AGS Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study (ASSISTS)



Status:Enrolling by invitation
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:18 - 85
Updated:3/31/2019
Start Date:February 2016
End Date:January 2023

Use our guide to learn which trials are right for you!

The AGS Second Aqueous Shunt Implant vs. Transscleral Cyclophotocoagulation Treatment Study

Outcomes of subjects with uncontrolled glaucoma with a single existing aqueous tube shunt
implant undergoing a second aqueous shunt to transscleral diode laser cyclophotocoagulation.

This is a study comparing short- (1 year), mid- (3 years), and long-term (5 years) cumulative
incidences of failures in participants who undergo a second aqueous shunt (SAS) to those
cumulative incidences of failures in participants who undergo a second aqueous shunt (SAS) to
those cumulative incidences of failures in participants who undergo transscleral diode laser
cyclophotocoagulation (TLC) for eyes with uncontrolled glaucoma with a single existing
aqueous tube shunt procedure.

Inclusion Criteria:

- Women and men 18 to 85 years of age

- Glaucoma not adequately controlled (IOP >18 mmHg on maximum tolerated topical therapy)
with a single aqueous shunt (AS).

- Best-corrected visual acuity (BCVA) of hand motion (HM) or better in the study eye

Exclusion Criteria:

- Monocular

- Presence of more than one AS in the study eye

- Previous cyclodestruction in the study eye

- Presence of active iris neovascularization in the study eye

- Binocular diplopia

- Presence of scleral buckle in the study eye

- History or scleritis in either eye

- History of scleromalacia in the study eye

- Insufficient conjunctiva to cover AS in the study eye

- IOP cannot be accurately measured with Goldmann applanation, Pneumotonometry, or
Tono-Pen in the study eye

- Presence of silicone oil in the study eye

- Presence of retinal detachment in the study eye

- Presence of intraocular or orbital tumor affecting the study eye

- Need for cataract extraction or concurrent procedure at the time of study treatment,
except tectonic aqueous shunt revisions for both groups is allowed.

- In the opinion of the investigator, should not be enrolled in this study

- Unwilling or unable to give consent and satisfy requirements of the study
We found this trial at
23
sites
?
mi
from
Overland Park, KS
Click here to add this to my saved trials
Los Angeles, California 90033
213) 740-2311
University of Southern California The University of Southern California is one of the world’s leading...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
243 Charles St
Boston, Massachusetts 02114
(617) 523-7900
Principal Investigator: Ambika Hoguet, MD
Phone: 617-573-6060
Massachusetts Eye & Ear Infirmary Whether you see our physicians at Mass. Eye and Ear's...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Boston, Massachusetts 02111
?
mi
from
Boston, MA
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
Principal Investigator: David Fleischman, MD
Phone: 919-843-0076
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
1215 Lee St
Charlottesville, Virginia 22903
(434) 924-0211
University of Virginia Health System UVA Health System includes a 604-bed hospital, level I trauma...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
Chesterfield, Missouri 63017
?
mi
from
Chesterfield, MO
Click here to add this to my saved trials
303 E Chicago Ave
Chicago, Illinois 60611
(312) 503-8194
Northwestern University Feinberg School of Medicine Northwestern University Feinberg School of Medicine, founded in 1859,...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Houston, Texas 77030
Principal Investigator: Nicholas P Bell, MD
Phone: 713-559-5200
?
mi
from
Houston, TX
Click here to add this to my saved trials
9415 Campus Point Drive
La Jolla, California 92093
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
900 Northwest 17th Street
Miami, Florida 33136
?
mi
from
Miami, FL
Click here to add this to my saved trials
Morgantown, West Virginia 26506
?
mi
from
Morgantown, WV
Click here to add this to my saved trials
Nashville, Tennessee 37232
Principal Investigator: Rachel Kuchtey, MD, PhD
Phone: 615-936-1639
?
mi
from
Nashville, TN
Click here to add this to my saved trials
?
mi
from
New York, NY
Click here to add this to my saved trials
?
mi
from
New York, NY
Click here to add this to my saved trials
185 South Orange Avenue
Newark, New Jersey 07103
?
mi
from
Newark, NJ
Click here to add this to my saved trials
Palm Beach Gardens, Florida 33418
Principal Investigator: Krishna Kishor, MD
Phone: 561-515-1534
?
mi
from
Palm Beach Gardens, FL
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19107
Principal Investigator: Anand Mantravadi, MD
Phone: 215-928-3123
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15213
Principal Investigator: Ian Conner, MD, PhD
Phone: 412-383-9884
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Portland, Oregon 97210
Principal Investigator: Steven L Mansberger, MD
Phone: 503-413-6505
?
mi
from
Portland, OR
Click here to add this to my saved trials
Richmond, Virginia 23226
Principal Investigator: Francis A. La Rosa, MD
Phone: 804-287-8516
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Rochelle Park, New Jersey 07062
?
mi
from
Rochelle Park, NJ
Click here to add this to my saved trials
Seattle, Washington 98014
Principal Investigator: Joanne Wen, MD
Phone: 206-221-3121
?
mi
from
Seattle, WA
Click here to add this to my saved trials