Study to Assess the Efficacy and Safety of Ublituximab + TGR-1202 With or Without Bendamustine and TGR-1202 Alone in Patients With Previously Treated Non-Hodgkins Lymphoma
Status: | Recruiting |
---|---|
Conditions: | Lymphoma |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 3/6/2019 |
Start Date: | June 2016 |
End Date: | July 2019 |
Contact: | TG Therapeutics Clinical Support Team |
Email: | clinicalsupport@tgtxinc.com |
Phone: | 212-554-4279 |
A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 With or Without Bendamustine and TGR-1202 Alone in Patients With Previously Treated Non-Hodgkin's Lymphoma
This research study will evaluate the safety and efficacy of a study drug called TGR-1202 in
combination with another study drug called ublituximab with or without bendamustine and
TGR-1202 alone as a possible treatment for Non-Hodgkin's Lymphoma (NHL) that has come back or
that has not responded to standard treatment.
combination with another study drug called ublituximab with or without bendamustine and
TGR-1202 alone as a possible treatment for Non-Hodgkin's Lymphoma (NHL) that has come back or
that has not responded to standard treatment.
Inclusion Criteria:
- Diagnosis of Non-Hodgkin's Lymphoma including Diffuse Large B-cell Lymphoma,
Follicular, Small Lymphocytic and Marginal Zone Lymphoma
- Relapsed or refractory to prior standard therapy and subjects who are not candidates
for high-dose therapy or autologous stem cell transplant
- Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
Exclusion Criteria:
- Any major surgery, chemotherapy or immunotherapy within the last 21 days
- Evidence of hepatitis B virus, hepatitis C virus or known HIV infection
- Autologous hematologic stem cell transplant within 6 months of study entry. Prior
Allogeneic hematologic stem cell transplant is excluded
- Prior therapy with a PI3K delta inhibitor
We found this trial at
106
sites
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